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鉴定甲状腺癌细胞肿瘤微环境中作为替代物的 microRNA-221 和 microRNA-222 的转录水平变化。

Identification of transcriptional level variations in microRNA-221 and microRNA-222 as alternate players in the thyroid cancer tumor microenvironment.

机构信息

Department of Zoology, PMAS-Arid Agriculture University, Rawalpindi, Pakistan.

Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan.

出版信息

Sci Rep. 2023 Sep 22;13(1):15800. doi: 10.1038/s41598-023-42941-1.

DOI:10.1038/s41598-023-42941-1
PMID:37737255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10516937/
Abstract

Thyroid cancer (TC) is caused by genetic factors and or their cross talk with lifestyle and environment. An important role of miRNA involvement has been identified in different human diseases alongside the cancer. The growing cloud of miRNA discoveries narrates miRNA-221 and miRNA-222 as key elements of ready arsenal in the cancer micro-niches. The aim of present study was to identify the variations of miRNA-221 and miRNA-222 expression in TC tissues and their likely association with TC. miRNA-221 and miRNA-222 were investigated for their expressional alterations in TC tissue samples and healthy thyroid tissue. Expression of miRNA-221 and -222 was analyzed through real time PCR. The relative gene expression of both the miRNA was quantified and statistically evaluated. miRNA-221 and miRNA-222 were found to be highly over expressed when compared with samples of multinodular goiter (MNG) and normal controls. Interestingly, it was also noted that miRNA-221 and miRNA-222 expression is working in a cluster in thyroid cancer patients. So, it can be concluded that the expressional alterations of miRNA-221 and -222 are playing their potential role in the development of thyroid cancer.

摘要

甲状腺癌（TC）是由遗传因素及其与生活方式和环境的相互作用引起的。miRNA 的参与在不同的人类疾病中，以及癌症中都被确定具有重要作用。越来越多的 miRNA 发现表明，miRNA-221 和 miRNA-222 是癌症微环境中重要武器库的关键要素。本研究旨在确定 miRNA-221 和 miRNA-222 在 TC 组织中的表达变化及其与 TC 的可能关联。研究人员研究了 miRNA-221 和 miRNA-222 在 TC 组织样本和健康甲状腺组织中的表达变化。通过实时 PCR 分析了 miRNA-221 和 -222 的表达。对两种 miRNA 的相对基因表达进行了定量和统计学评估。与多结节性甲状腺肿（MNG）和正常对照组相比，miRNA-221 和 miRNA-222 的表达明显过高。有趣的是，还注意到 miRNA-221 和 miRNA-222 的表达在甲状腺癌患者中呈簇状。因此，可以得出结论，miRNA-221 和 -222 的表达改变在甲状腺癌的发生发展中发挥着潜在作用。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3dbc/10516937/fe6fd6372ed4/41598_2023_42941_Fig7_HTML.jpg
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