VA Boston Healthcare System, Boston, Massachusetts, USA.
Trans Divisional Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Neuro Oncol. 2024 Feb 2;26(2):387-396. doi: 10.1093/neuonc/noad182.
Comprehensive analysis of brain tumor incidence and survival in the Veteran population has been lacking.
Veteran data were obtained from the Veterans Health Administration (VHA) Medical Centers via VHA Corporate Data Warehouse. Brain tumor statistics on the overall US population were generated from the Central Brain Tumor Registry of the US data. Cases were individuals (≥18 years) with a primary brain tumor, diagnosed between 2004 and 2018. The average annual age-adjusted incidence rates (AAIR) and 95% confidence intervals were estimated per 100 000 population and Kaplan-Meier survival curves evaluated overall survival outcomes among Veterans.
The Veteran population was primarily white (78%), male (93%), and between 60 and 64 years old (18%). Individuals with a primary brain tumor in the general US population were mainly female (59%) and between 18 and 49 years old (28%). The overall AAIR of primary brain tumors from 2004 to 2018 within the Veterans Affairs cancer registry was 11.6. Nonmalignant tumors were more common than malignant tumors (AAIR:7.19 vs 4.42). The most diagnosed tumors in Veterans were nonmalignant pituitary tumors (AAIR:2.96), nonmalignant meningioma (AAIR:2.62), and glioblastoma (AAIR:1.96). In the Veteran population, survival outcomes became worse with age and were lowest among individuals diagnosed with glioblastoma.
Differences between Veteran and US populations can be broadly attributed to demographic composition differences of these groups. Prior to this, there have been no reports on national-level incidence rates and survival outcomes for Veterans. These data provide vital information that can drive efforts to understand disease burden and improve outcomes for individuals with primary brain tumors.
缺乏对退伍军人人群中脑肿瘤发病率和生存率的综合分析。
退伍军人数据来自退伍军人健康管理局（VHA）医疗中心，通过 VHA 公司数据仓库获得。美国总人口的脑肿瘤统计数据来自美国中央脑肿瘤登记处的数据。病例为 2004 年至 2018 年间诊断出患有原发性脑肿瘤的个体（≥18 岁）。每 10 万人的平均年龄调整发病率（AAIR）和 95%置信区间是根据人口计算的，Kaplan-Meier 生存曲线评估了退伍军人的总体生存结果。
退伍军人人群主要为白人（78%）、男性（93%），年龄在 60 至 64 岁之间（18%）。美国普通人群中患有原发性脑肿瘤的个体主要为女性（59%），年龄在 18 至 49 岁之间（28%）。退伍军人癌症登记处 2004 年至 2018 年期间原发性脑肿瘤的总体 AAIR 为 11.6。良性肿瘤比恶性肿瘤更为常见（AAIR：7.19 比 4.42）。退伍军人中最常见的肿瘤是非恶性垂体瘤（AAIR：2.96）、非恶性脑膜瘤（AAIR：2.62）和胶质母细胞瘤（AAIR：1.96）。在退伍军人人群中，随着年龄的增长，生存结果变得更糟，而被诊断为胶质母细胞瘤的个体的生存结果最差。
退伍军人和美国人群之间的差异可以广泛归因于这些人群的人口组成差异。在此之前，尚无关于退伍军人全国发病率和生存结果的报告。这些数据提供了重要信息，可以推动努力了解疾病负担并改善原发性脑肿瘤患者的结局。
