Breslow R A, Alberg A J, Helzlsouer K J, Bush T L, Norkus E P, Morris J S, Spate V E, Comstock G W
National Cancer Institute, Cancer Prevention Fellowship Program, Bethesda 20852, USA.
Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):837-42.
To determine the association between prediagnostic serum levels of retinol, beta-carotene, lycopene, alpha-tocopherol, and selenium and the subsequent risk of malignant melanoma, and basal and squamous cell skin cancer, a nested case-control study among residents of Washington County, MD, was performed. Cases with melanoma (n = 30), basal cell (n = 32), and squamous cell (n = 37) skin cancer who were admitted to hospital for treatment or biopsy of metastatic lesions were each matched by age, sex, and race with two controls. There were no significant associations between serum micronutrient levels and the risk of subsequent skin cancer.
为了确定诊断前血清视黄醇、β-胡萝卜素、番茄红素、α-生育酚和硒水平与随后发生恶性黑色素瘤、基底细胞癌和鳞状细胞皮肤癌风险之间的关联，在马里兰州华盛顿县居民中进行了一项巢式病例对照研究。因转移性病变入院接受治疗或活检的黑色素瘤患者（n = 30）、基底细胞癌患者（n = 32）和鳞状细胞癌患者（n = 37），每例均按年龄、性别和种族与两名对照进行匹配。血清微量营养素水平与随后发生皮肤癌的风险之间无显著关联。
