FSP1 oxidizes NADPH to suppress ferroptosis.
作者信息
Zhang Sitao, Gou Shengsong, Zhang Qian, Yong Xin, Gan Boyi, Jia Da
机构信息
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan, China.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Cell Res. 2023 Dec;33(12):967-970. doi: 10.1038/s41422-023-00879-z. Epub 2023 Sep 22.
Abstract
摘要
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本文引用的文献
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A non-canonical vitamin K cycle is a potent ferroptosis suppressor.非经典维生素 K 循环是一种有效的铁死亡抑制因子。
Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3.
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Targeting ferroptosis as a vulnerability in cancer.针对癌症中的铁死亡脆弱性。
Nat Rev Cancer. 2022 Jul;22(7):381-396. doi: 10.1038/s41568-022-00459-0. Epub 2022 Mar 25.
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Ferroptosis: mechanisms, biology and role in disease.铁死亡：机制、生物学及其在疾病中的作用
Nat Rev Mol Cell Biol. 2021 Apr;22(4):266-282. doi: 10.1038/s41580-020-00324-8. Epub 2021 Jan 25.
4
Apoptosis inducing factor and mitochondrial NADH dehydrogenases: redox-controlled gear boxes to switch between mitochondrial biogenesis and cell death.凋亡诱导因子和线粒体 NADH 脱氢酶：氧化还原控制的变速箱，用于在线粒体生物发生和细胞死亡之间切换。
Biol Chem. 2020 Aug 25;402(3):289-297. doi: 10.1515/hsz-2020-0254. Print 2021 Feb 23.
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Nat Metab. 2020 Mar;2(3):270-277. doi: 10.1038/s42255-020-0181-1. Epub 2020 Mar 9.
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Trends Cell Biol. 2020 Jun;30(6):478-490. doi: 10.1016/j.tcb.2020.02.009. Epub 2020 Mar 21.
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Ferroptosis: past, present and future.铁死亡：过去、现在和未来。
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FSP1 is a glutathione-independent ferroptosis suppressor.FSP1 是一种谷胱甘肽不依赖的铁死亡抑制因子。
Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21.
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Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.定义由NADH驱动的变构调节凋亡诱导因子
Structure. 2016 Dec 6;24(12):2067-2079. doi: 10.1016/j.str.2016.09.012. Epub 2016 Nov 3.
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