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有证据表明阿片类药物成瘾部分是一种免疫反应。辐射破坏免疫系统改变了阿片类药物戒断反应。

Evidence that opiate addiction is in part an immune response. Destruction of the immune system by irradiation-altered opiate withdrawal.

作者信息

Dafny N, Pellis N R

出版信息

Neuropharmacology. 1986 Aug;25(8):815-8. doi: 10.1016/0028-3908(86)90003-1.

DOI:10.1016/0028-3908(86)90003-1
PMID:3774111
Abstract

Experiments were performed to determine whether physical dependence on opiates (CNS phenomena) can be altered by destruction of the immune system. Irradiation, prior to or after chronic treatment with morphine significantly reduced the opiate-withdrawal syndrome as assessed by naloxone-induced abstinence. This study supports the proposition that addiction to opiates is related, at least in part, to interaction between the central nervous system (CNS) and the immune system.

摘要

开展实验以确定免疫系统被破坏是否会改变对阿片类药物的身体依赖性（中枢神经系统现象）。在长期使用吗啡之前或之后进行辐照，通过纳洛酮诱导的戒断反应评估，显著减轻了阿片类药物戒断综合征。本研究支持这样一种观点，即对阿片类药物的成瘾至少部分与中枢神经系统（CNS）和免疫系统之间的相互作用有关。

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1
Evidence that opiate addiction is in part an immune response. Destruction of the immune system by irradiation-altered opiate withdrawal.有证据表明阿片类药物成瘾部分是一种免疫反应。辐射破坏免疫系统改变了阿片类药物戒断反应。
Neuropharmacology. 1986 Aug;25(8):815-8. doi: 10.1016/0028-3908(86)90003-1.
2
Cyclosporine alters opiate withdrawal in rodents.环孢素改变啮齿动物的阿片类药物戒断反应。
Life Sci. 1985 May 6;36(18):1721-6. doi: 10.1016/0024-3205(85)90554-5.
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Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats.淋巴细胞在阿片类药物依赖大鼠戒断综合征中的作用。
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Single injection of three different preparations of alpha-interferon modifies morphine abstinence signs for a prolonged period.
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The immune system and opiate withdrawal.免疫系统与阿片类药物戒断反应
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Three different types of alpha-interferons alter naloxone-induced abstinence in morphine-addicted rats.三种不同类型的α-干扰素可改变吗啡成瘾大鼠中纳洛酮诱发的戒断反应。
Immunopharmacology. 1985 Feb;9(1):13-7. doi: 10.1016/0162-3109(85)90041-4.
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Evidence of neuro-immunologic interactions: cyclosporine modifies opiate withdrawal by effects on the brain and immune components.神经免疫相互作用的证据：环孢素通过对大脑和免疫成分的作用来改变阿片类药物戒断反应。
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The immune system and morphine dependence.免疫系统与吗啡依赖。
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Enigmatic action of ciclosporine A on the naloxone-precipitated morphine withdrawal syndrome in mice.环孢素A对小鼠纳洛酮诱发的吗啡戒断综合征的神秘作用。
Neuroscience. 1989;31(1):97-103. doi: 10.1016/0306-4522(89)90032-8.
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Interferon modifies morphine withdrawal phenomena in rodents.干扰素可改变啮齿动物的吗啡戒断现象。
Neuropharmacology. 1983 May;22(5):647-51. doi: 10.1016/0028-3908(83)90157-0.

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Effects of opioid tolerance and withdrawal on the immune system.阿片类药物耐受性和戒断对免疫系统的影响。
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