免疫系统与阿片类药物戒断反应

The immune system and opiate withdrawal.

作者信息

Dafny N, Dougherty P M, Pellis N R

机构信息

Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.

出版信息

Int J Immunopharmacol. 1989;11(4):371-5. doi: 10.1016/0192-0561(89)90083-0.

DOI:10.1016/0192-0561(89)90083-0

PMID:2674032

Abstract

Whole body exposure to 500 rad ionizing irradiation suppresses the immune system in rats. Moreover, when administered prior to chronic morphine treatment, irradiation exposure also dramatically reduces the severity of naloxone-precipitated withdrawal in morphine dependent animals. The reinstillment of 2-6 x 10(8) normal lymphoid immunocompetent cells to irradiated rats by adoptive transfer prior to chronic morphine treatment restores all withdrawal signs precipitated by naloxone injection. The data suggest that specific cellular activities or factors derived from lymphoid cells are required for the expression of opiate withdrawal, indicating that the immune system participates in the manifestation of opiate dependence.

摘要

对大鼠进行全身500拉德的电离辐射会抑制其免疫系统。此外，在慢性吗啡治疗前给予辐射暴露，还会显著降低吗啡依赖动物中纳洛酮诱发的戒断症状的严重程度。在慢性吗啡治疗前，通过过继转移给受辐照大鼠重新注入2 - 6×10⁸个正常具有免疫活性的淋巴细胞，可恢复纳洛酮注射诱发的所有戒断症状。这些数据表明，阿片类药物戒断症状的表现需要淋巴细胞产生的特定细胞活性或因子，这表明免疫系统参与了阿片类药物依赖的表现。