淋巴细胞在阿片类药物依赖大鼠戒断综合征中的作用。

Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats.

作者信息

Pellis N R, Kletzly N E, Dougherty P M, Aronowski J, Dafny N

出版信息

Life Sci. 1987 Apr 20;40(16):1589-93. doi: 10.1016/0024-3205(87)90124-x.

Abstract

Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 X 10(8) lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.

摘要

在长期给予吗啡之前，先用500拉德全身电离辐射处理大鼠，可减轻纳洛酮诱发的戒断症状的严重程度。相比之下，在长期吗啡处理之前，将2-6×10⁸个淋巴细胞过继转移给受辐射的大鼠，可完全恢复其出现纳洛酮诱发的戒断症状的能力。这些观察结果提示免疫系统可能参与了阿片类药物成瘾过程。