U.G.C. Medico-Quirurgica de Enfermedades Respiratorias, Hospital Regional Universitario de Malaga, Malaga, Spain.
Department of Computer Architecture, University of Malaga, Malaga, Spain.
Mol Biol Rep. 2023 Nov;50(11):9521-9527. doi: 10.1007/s11033-023-08695-9. Epub 2023 Sep 23.
Lung cancer has a high prevalence and mortality due to its late diagnosis and limited treatment, so it is essential to find biomarkers that allow a faster diagnosis and improve the survival of these patients. In this sense, biomarkers based on miRNAs have supposed a considerable advance. miRNAs, which are small RNA sequences, can regulate gene expression, so they play an essential role not only as a diagnostic biomarker but also as a therapeutic and prognostic one. Also, miRNA biomarkers can be obtained from liquid biopsies, which are less intrusive than lung biopsies, and have better accessibility, safety and repeatability, which allows using those biomarkers both for diagnosis and monitoring of patients. In this review, we highlight the importance of miRNAs and collect the existing evidence of their relationship with lung cancer.
由于肺癌晚期诊断和治疗有限，其发病率和死亡率较高，因此寻找能够更快诊断和改善这些患者生存的生物标志物至关重要。在这方面，基于 miRNA 的生物标志物取得了相当大的进展。miRNA 是一种小型 RNA 序列，可以调节基因表达，因此它们不仅作为诊断生物标志物，而且作为治疗和预后生物标志物发挥着重要作用。此外，miRNA 生物标志物可以从液体活检中获得，与肺活检相比，液体活检的侵入性更小，并且具有更好的可及性、安全性和可重复性，这使得这些生物标志物既可以用于诊断，也可以用于监测患者。在这篇综述中，我们强调了 miRNA 的重要性，并收集了它们与肺癌关系的现有证据。
