Malekzadeh Gonabadi Najmeh, Shamsara Mehdi, Kordi Tamandani Dor Mohammad, Shojaei Sahar, Alavi Seyed Mehdi
Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
Department of Animal Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
J Lasers Med Sci. 2023 Aug 30;14:e31. doi: 10.34172/jlms.2023.31. eCollection 2023.
Different kinds of treatments have been developed to fight cancers. Low-level laser therapy (LLLT), also known as photobiomodulation therapy (PBMT), is a low-power monochromatic and coherent light that has been used successfully for healing injuries and combating malignancies. However, there are concerns about the application of LLLT to cancers due to the increased proliferation of some cancer cells after LLLT. This study investigated the effects of 650 nm and 870 nm lasers on the proliferation of HT29 colorectal cancer cell lines and . The results showed that the laser with a wavelength of 870 nm did not meaningfully alter the proliferation of cultured cells. However, cell proliferation was promoted when the laser was applied within a wavelength of 650 nm. Treatment of HT29-derived tumors in nude mice with the 650 nm laser resulted in the decline of the tumor progression rate compared to controls. This result was inconsistent with the proliferative effects of the laser on the cultured cells. Cell behavior in response to LLLT might be different between cell culture and xenograft models.
人们已经开发出了不同的癌症治疗方法。低强度激光疗法（LLLT），也称为光生物调节疗法（PBMT），是一种低功率的单色相干光，已成功用于伤口愈合和对抗恶性肿瘤。然而，由于低强度激光疗法后一些癌细胞的增殖增加，人们对其在癌症治疗中的应用存在担忧。本研究调查了650纳米和870纳米激光对HT29结肠癌细胞系增殖的影响。结果表明，波长为870纳米的激光对培养细胞的增殖没有显著影响。然而，当应用波长为650纳米的激光时，细胞增殖得到促进。与对照组相比，用650纳米激光治疗裸鼠体内源自HT29的肿瘤导致肿瘤进展率下降。这一结果与激光对培养细胞的增殖作用不一致。细胞培养模型和异种移植模型中细胞对低强度激光疗法的反应行为可能不同。
