Alashetty Soumya, Sadasivan Balu, Dharmalingam Priya, Rajagopal Nethra, Kavya Lucas, Pai Malathi M
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India.
Department of Pathology, Yenepoya Medical College, Mangalore, Karnataka, India.
J Cytol. 2023 Jul-Sep;40(3):107-113. doi: 10.4103/joc.joc_107_22. Epub 2023 Aug 14.
Serous effusion cytology (SEC) reporting is important for the management of the cancer patient. The International System for Reporting Serous Fluid Cytology (ISRSFC) provides tiered reporting terminology to standardize practice, looking into the risk of malignancy (MAL) for each category. In this study, we have assessed the utility of the ISRSFC and reported our experience at a tertiary cancer center.
Serous fluid cytology reported from January 2019 to December 2020 was categorized according to ISRSFC diagnostic categories: nondiagnostic (ND), negative for MAL (NFM), atypia of undetermined significance (AUS), suspicious for MAL (SFM), and MAL. The risk of MAL (ROM) and performance parameters were calculated.
A total of 2150 serous effusions including 1160 pleural, 929 peritoneal, and 61 pericardial effusions from 2071 patients were reported. There were 742 males and 1329 females. The patient's age ranged from less than 1 yr to 95 years. The volume of the sample ranged from 0.5 ml to 2000 ml. There were 114 ND (5.32%), 1068 NFM (49.67%), 144 AUS (6.69%), 82 SFM (3.81%), and 742 MAL (34.51%) cases. Adenocarcinoma was the most common MAL involving serous fluids (91.50%). The calculated ROM was 15.38% for ND, 24.26% for NFM, 62.96% for AUS, 79.16% for SFM, and 100% for MAL. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were, respectively, 68.04%, 96.96%, 96.35%, 72.07%, and 81.33%.
ISRSFC provides consistent reporting terminology and the ROM for each category aids in clinical correlation and management.
浆液性积液细胞学（SEC）报告对于癌症患者的管理至关重要。国际浆液性液体细胞学报告系统（ISRSFC）提供了分级报告术语，以规范实践，并研究每个类别的恶性肿瘤风险（MAL）。在本研究中，我们评估了ISRSFC的实用性，并报告了我们在一家三级癌症中心的经验。
将2019年1月至2020年12月报告的浆液性液体细胞学根据ISRSFC诊断类别进行分类：无法诊断（ND）、MAL阴性（NFM）、意义未明的非典型性（AUS）、MAL可疑（SFM）和MAL。计算MAL风险（ROM）和性能参数。
共报告了来自2071例患者的2150例浆液性积液，包括1160例胸腔积液、929例腹腔积液和61例心包积液。男性742例，女性1329例。患者年龄从小于1岁到95岁不等。样本量从0.5毫升到2000毫升不等。有114例ND（5.32%）、1068例NFM（49.67%）、144例AUS（6.69%）、82例SFM（3.81%）和742例MAL（34.51%）病例。腺癌是涉及浆液性液体的最常见MAL（91.50%）。计算出的ROM对于ND为15.38%，对于NFM为24.26%，对于AUS为62.96%，对于SFM为79.16%，对于MAL为100%。敏感性、特异性、阳性预测值、阴性预测值和诊断准确性分别为68.04%、96.96%、96.35%、72.07%和81.33%。
ISRSFC提供了一致的报告术语，每个类别的ROM有助于临床关联和管理。
