Pinto Daniel, Cruz Eduardo, Branco Diamantina, Linares Cláudia, Carvalho Conceição, Silva Amélia, Chorão Martinha, Schmitt Fernando
Serviço de Anatomia Patológica, Centro Hospitalar de Lisboa Ocidental, EPE, 1349-019 Lisboa, Portugal.
NOVA Medical School, 1169-056 Lisboa, Portugal.
Diagnostics (Basel). 2021 Jun 20;11(6):1126. doi: 10.3390/diagnostics11061126.
The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research.
国际浆液性液体细胞学报告系统（TIS）最近得以开发。鉴于其新颖性，大多数探究浆液性积液诊断类别恶性风险（ROM）的研究是在TIS开发之前发表的。我们在本部门数据库中搜索了过去五年诊断的胸腔积液病例，排除了那些没有相应胸膜活检的病例。根据TIS对病例进行复查和重新分类。进行了细胞组织学相关性分析。总共纳入了350份有一份或多份相应胸膜活检的胸腔积液标本。重新分类后，5例（1.43%）为无法诊断（ND），253例（72.29%）为恶性阴性（NFM），7例（2.00%）为意义不明的非典型性（AUS），14例（4.00%）为恶性可疑（SFM），71例（20.57%）为恶性（MAL）。计算得出的ND的ROM为40%，NFM为20.16%，AUS为42.86%，SFM为78.57%，MAL为100%。积液细胞学的敏感性和特异性分别为60.29%和98.56%。这是第一篇基于TIS对胸腔积液回顾性队列进行细胞组织学相关性分析的出版物。我们补充了有关TIS类别ROM的数据，突出了未来潜在的研究领域。
