Wang Tengfei, Rampisela Debby
Pathology, Baylor Scott & White Health, Temple, USA.
Cureus. 2023 Aug 24;15(8):e44050. doi: 10.7759/cureus.44050. eCollection 2023 Aug.
Visceral leishmaniasis (VL) is a form of leishmaniasis, which causes significant mortality if untreated. The coexistence of VL with infection has not been well-documented in the literature. In this paper, we present the case of a 72-year-old male who experienced four months of recurrent diarrhea and later developed weight loss, fever, night sweats, and pancytopenia. The stool ova and parasite (O&P) examination revealed spp. vacuolar bodies and he was treated with metronidazole which resolved the diarrhea but not other symptoms. Further evaluation, including an abdominal Computed Tomogram (CT) scan and ultrasonography (USG), revealed splenomegaly. A splenic biopsy confirmed VL with numerous amastigotes. Treatment with Amphotericin B led to clinical improvement. This paper discusses the clinical and diagnostic features of VL and s, highlighting their differential diagnosis, and available treatments.
内脏利什曼病（VL）是利什曼病的一种形式，若不治疗会导致显著的死亡率。VL与感染并存的情况在文献中尚未得到充分记载。在本文中，我们报告了一例72岁男性病例，该患者经历了四个月的反复腹泻，随后出现体重减轻、发热、盗汗和全血细胞减少。粪便虫卵和寄生虫（O&P）检查发现了 spp. 液泡体，他接受了甲硝唑治疗，腹泻症状得到缓解，但其他症状未改善。进一步评估，包括腹部计算机断层扫描（CT）和超声检查（USG），发现脾肿大。脾脏活检证实为VL，有大量无鞭毛体。两性霉素B治疗使临床症状得到改善。本文讨论了VL和s的临床及诊断特征，强调了它们的鉴别诊断和可用治疗方法。
