Makkena Vijaya Krishna, Jaramillo Arturo P, Awosusi Babatope L, Ayyub Javaria, Dabhi Karan Nareshbha, Gohil Namra V, Tanveer Nida, Hussein Sally, Pingili Shravya, Khan Safeera
Department of Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Department of Medicine, Osmania Medical College, Hyderabad, IND.
Cureus. 2023 Aug 21;15(8):e43892. doi: 10.7759/cureus.43892. eCollection 2023 Aug.
Prostate neoplasia is one of the most commonly occurring neoplasias in males and has a high mortality rate. Prostate cancer (PCA) risk factors include tall stature, male sex, known family history, obesity, high blood pressure, lack of fitness, higher levels of testosterone for a long time, increasing age, and ethnicity are well known. The association and role of the gut microbiota in different diseases in our body have been highlighted recently. Therefore, finding the influence of gut microbiota on the prostatic cells can be useful for preventing prostatic neoplasia and/or reducing its severity. We aimed to assess its impact on PCA risk. We thoroughly searched databases for the relevant literature for our systematic review. The final research papers analyzed how bacteria played a role in the risk of PCA, either through inflammation or the production of metabolites that increase/decrease the risk of PCA. Based on the studies reviewed, we found that some gut bacteria play a role in the formation of PCA. In contrast, some bacteria can help prevent PCA, but the metabolism of the dietary components is the major factor for PCA.
前列腺肿瘤是男性最常见的肿瘤之一，死亡率很高。前列腺癌（PCA）的风险因素包括身材高大、男性性别、已知家族病史、肥胖、高血压、缺乏运动、长期高水平的睾酮、年龄增长以及种族等，这些都是众所周知的。肠道微生物群在我们身体不同疾病中的关联和作用最近受到了关注。因此，了解肠道微生物群对前列腺细胞的影响可能有助于预防前列腺肿瘤和/或降低其严重程度。我们旨在评估其对PCA风险的影响。我们全面检索了数据库以获取相关文献用于我们的系统评价。最终的研究论文分析了细菌如何通过炎症或产生增加/降低PCA风险的代谢产物在PCA风险中发挥作用。基于所综述的研究，我们发现一些肠道细菌在PCA的形成中起作用。相比之下，一些细菌有助于预防PCA，但饮食成分的代谢是PCA的主要因素。
