Kumar Harendra, Boini Aishwarya, Tshibangu Mpuekela, Ghosh Bikona, Shaheen Fatima, Joseph Andrew M, Cazzaniga Juliana, Karas Monica, Jara Silva Cesar E, Quinonez Jonathan, Ruxmohan Samir
Medicine and Surgery, Dow University of Health Sciences, Karachi, PAK.
Medicine, Government Medical College and Hospital, Siddipet, IND.
Cureus. 2023 Aug 22;15(8):e43899. doi: 10.7759/cureus.43899. eCollection 2023 Aug.
Anticoagulation therapy is critical to avoiding thrombotic events in patients following cranial surgery. Although Aspirin, Plavix, and Aggrastat are used as anticoagulants for this purpose, there is no consensus on which agent is the most effective and safe. In this comparative study, we analyze the current evidence on the efficacy and safety of these three anticoagulants in the context of cranial surgeries. This review focuses on the advantages and disadvantages of each anticoagulant, such as its pharmacokinetics, indications, contraindications, and possible consequences. The outcomes of this study will help physicians choose the best anticoagulant for their patients based on individual patient characteristics and the kind of cranial procedure. Aggrastat's potential to be included as a recommended anticoagulant for cranial procedures warrants further study.
抗凝治疗对于避免颅脑手术后患者发生血栓事件至关重要。虽然阿司匹林、波立维及阿昔单抗为此被用作抗凝剂，但对于哪种药物最有效且安全尚无共识。在这项对比研究中，我们分析了有关这三种抗凝剂在颅脑手术中疗效及安全性的现有证据。本综述聚焦于每种抗凝剂的优缺点，例如其药代动力学、适应证、禁忌证及可能的后果。这项研究的结果将帮助医生根据患者个体特征及颅脑手术类型为其患者选择最佳抗凝剂。阿昔单抗被纳入颅脑手术推荐抗凝剂的可能性值得进一步研究。
