Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11000, Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.
Arch Gynecol Obstet. 2024 Mar;309(3):907-915. doi: 10.1007/s00404-023-07227-x. Epub 2023 Sep 25.
Polycystic ovary syndrome (PCOS) is the most common endocrine-reproductive disease linked not just to infertility but also to serious comorbidities. There is a reported association between low vitamin D levels and multiple health conditions including PCOS. This narrative review aims to analyze the role of vitamin D in PCOS development, use of the vitamin D in the treatment of PCOS, and the molecular basis of these observations.
A Medline and PubMed research was performed, during the years 1990-2023, using a combination of keywords on such topic. According to the author's evaluation and target, papers were identified and included for a narrative review.
There are associations between lower levels of vitamin D and PCOS, as well as with insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders as well as the onset of oxidative stress and pro-inflammatory milieu, in PCOS women.
Vitamin D has a role in pathologic changes linked to PCOS. Molecular and clinical investigations which give new information about the role of vitamin D in the development of PCOS and related endocrine and metabolic disturbance are further needed.
多囊卵巢综合征（PCOS）是最常见的内分泌-生殖疾病，不仅与不孕有关，还与严重的合并症有关。有报道称，维生素 D 水平低与多种健康状况有关，包括 PCOS。本综述旨在分析维生素 D 在 PCOS 发病机制中的作用、维生素 D 在 PCOS 治疗中的应用，以及这些观察结果的分子基础。
在 1990 年至 2023 年期间，使用与该主题相关的关键词组合，在 Medline 和 PubMed 上进行了文献检索。根据作者的评估和目标，确定并纳入了论文进行综述。
维生素 D 水平较低与 PCOS 以及胰岛素抵抗、代谢综合征、高雄激素血症、代谢和内分泌紊乱以及氧化应激和促炎环境的发生有关，在 PCOS 女性中。
维生素 D 在与 PCOS 相关的病理变化中起作用。需要进一步进行分子和临床研究，以提供关于维生素 D 在 PCOS 发展和相关内分泌及代谢紊乱中的作用的新信息。
