Department of Molecular Biology, University of California, San Diego, La Jolla, CA, United States.
Enzymes. 2023;53:1-6. doi: 10.1016/bs.enz.2023.03.002. Epub 2023 Apr 19.
Nucleosomes are intrinsically immobile, and thus, ATP-dependent chromatin remodeling factors are needed to alter nucleosomes to facilitate DNA-directed processes such as transcription. More generally, chromatin remodeling factors mediate chromatin dynamics, which encompasses nucleosome assembly, movement, and disruption as well as histone exchange. Here, I present selected thoughts and perspectives on the past, present, and future of these fascinating ATP-driven motor proteins.
核小体是固有不动的，因此需要 ATP 依赖性染色质重塑因子来改变核小体，以促进 DNA 指导的过程，如转录。更广泛地说，染色质重塑因子介导染色质动力学，包括核小体组装、运动和破坏以及组蛋白交换。在这里，我提出了对这些迷人的 ATP 驱动马达蛋白的过去、现在和未来的一些思考和观点。
