School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing, China.
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China.
Physiol Rep. 2023 Sep;11(18):e15831. doi: 10.14814/phy2.15831.
We aimed to compare the effects of three intensities of treadmill running on exercise-induced hypoalgesia (EIH) in healthy individuals. We anticipated that the primary and secondary changes in pain perception and modulation may differ between running intensities. Sixty-six women were randomly assigned to one of three treadmill running intensities for 35 min: 40% reserved heart rate (HRR), 55% HRR, or 70% HRR. The effects of EIH were assessed using pressure pain thresholds (PPT) and tolerance thresholds (PPTol). We measured conditional pain modulation (CPM). Compared with baseline, PPT and PPTol significantly increased in all groups during running and at the 5-10-min follow-up. The PPT and PPTol changes in the moderate- and low-intensity groups were significantly higher than those in the high-intensity group during running and 24 h after running, while the CPM responses of the high-intensity group were significantly reduced at the 24-h follow-up. Moderate- and low-intensity running may elicit significant primary and secondary (persisting over 24 h) EIH effects and increase CPM responses in females. However, high-intensity running induced only limited analgesic effects and reduced CPM responses, which may be attributed to the activation of endogenous pain modulation.
我们旨在比较三种强度的跑步机跑步对健康个体运动诱发镇痛（EIH）的影响。我们预计，疼痛感知和调节的主要和次要变化可能因跑步强度而异。66 名女性被随机分配到三种跑步机跑步强度中的一种，持续 35 分钟：40%储备心率（HRR）、55% HRR 或 70% HRR。使用压力疼痛阈值（PPT）和耐受阈值（PPTol）评估 EIH 的效果。我们测量了条件疼痛调制（CPM）。与基线相比，在所有组中，PPT 和 PPTol 在跑步期间和跑步后 5-10 分钟显著增加。在跑步期间和跑步后 24 小时，中低强度组的 PPT 和 PPTol 变化明显高于高强度组，而高强度组的 CPM 反应在 24 小时随访时明显降低。中低强度跑步可能会引起显著的原发性和继发性（持续超过 24 小时）EIH 效应，并增加女性的 CPM 反应。然而，高强度跑步仅引起有限的镇痛作用并降低 CPM 反应，这可能归因于内源性疼痛调制的激活。
