Zhang Hanwen, Yao Longping, Zheng Zijian, Koc Sumeyye, Lu Guohui
Department of Neurosurgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
The Center of Neuroscience, Life Science Zurich Graduate School, University of Zurich, 8091 Zurich, Switzerland.
Pharmaceuticals (Basel). 2022 Jun 30;15(7):811. doi: 10.3390/ph15070811.
Parkinson's disease (PD) is a prevalent neurodegenerative aging disorder that manifests as motor and non-motor symptoms, and its etiopathogenesis is influenced by non-coding RNAs (ncRNAs). Signal pathway and gene sequence studies have proposed that alteration of ncRNAs is relevant to the occurrence and development of PD. Furthermore, many studies on brain tissues and body fluids from patients with PD indicate that variations in ncRNAs and their target genes could trigger or exacerbate neurodegenerative pathogenesis and serve as potential non-invasive biomarkers of PD. Numerous ncRNAs have been considered regulators of apoptosis, α-syn misfolding and aggregation, mitochondrial dysfunction, autophagy, and neuroinflammation in PD etiology, and evidence is mounting for the determination of the role of competing endogenous RNA (ceRNA) mechanisms in disease development. In this review, we discuss the current knowledge regarding the regulation and function of ncRNAs as well as ceRNA networks in PD pathogenesis, focusing on microRNAs, long ncRNAs, and circular RNAs to increase the understanding of the disease and propose potential target identification and treatment in the early stages of PD.
帕金森病（PD）是一种常见的神经退行性衰老疾病，表现为运动和非运动症状，其发病机制受非编码RNA（ncRNAs）影响。信号通路和基因序列研究表明，ncRNAs的改变与PD的发生发展有关。此外，许多针对PD患者脑组织和体液的研究表明，ncRNAs及其靶基因的变化可能引发或加剧神经退行性病变的发病机制，并可作为PD潜在的非侵入性生物标志物。在PD病因学中，众多ncRNAs被认为是细胞凋亡、α-突触核蛋白错误折叠和聚集、线粒体功能障碍、自噬以及神经炎症的调节因子，并且越来越多的证据表明竞争性内源RNA（ceRNA）机制在疾病发展中的作用。在这篇综述中，我们讨论了目前关于ncRNAs以及ceRNA网络在PD发病机制中的调控和功能的知识，重点关注微小RNA、长链非编码RNA和环状RNA，以增进对该疾病的理解，并提出在PD早期阶段潜在的靶点识别和治疗方法。
