Hill P, Thijssen J H, Garbaczewski L, Koppeschaar H P, de Waard F
Scand J Gastroenterol. 1986 Oct;21(8):958-60. doi: 10.3109/00365528608996403.
To determine the role of vasoactive intestinal polypeptide (VIP) and prolactin (PRL) in digestion, plasma VIP and PRL levels were measured in healthy, non-obese and obese premenopausal women fed isocaloric breakfasts containing a high carbohydrate or a high fat-protein content. A significant increase in plasma VIP concentration occurred after a high fat-protein breakfast, the increase being independent of body mass index. Plasma PRL level was unaltered by breakfast. Results suggest that the release of VIP after a meal depends on a high fat concentration in the duodenum, which may then stimulate bicarbonate release and fat-stimulated release of cholecystokinin.
为确定血管活性肠肽（VIP）和催乳素（PRL）在消化过程中的作用，对健康、非肥胖及肥胖的绝经前女性进行了研究，这些女性食用了含有高碳水化合物或高脂肪 - 蛋白质的等热量早餐，随后测量其血浆VIP和PRL水平。高脂肪 - 蛋白质早餐后，血浆VIP浓度显著升高，且这种升高与体重指数无关。早餐对血浆PRL水平无影响。结果表明，餐后VIP的释放取决于十二指肠中的高脂肪浓度，这可能会刺激碳酸氢盐释放以及胆囊收缩素的脂肪刺激释放。
