Department of Mathematics, Brigham Young University, Provo, Utah.
Department of Mathematics, Brigham Young University, Provo, Utah.
Biophys J. 2023 Nov 7;122(21):4160-4175. doi: 10.1016/j.bpj.2023.09.013. Epub 2023 Sep 25.
Here, we investigate how a subpopulation of cells can move through an aggregate of cells. Using a stochastic force-based model of Dictyostelium discoideum when the population is forming a slug, we simulate different strategies for prestalk cells to reliably move to the front of the slug while omitting interaction with the substrate thus ignoring the overall motion of the slug. Of the mechanisms that we simulated, prestalk cells being more directed is the best strategy followed by increased asymmetric motive forces for prestalk cells. The lifetime of the cell adhesion molecules, while not enough to produce differential motion, did modulate the results of the strategies employed. Finally, understanding and simulating the appropriate boundary conditions are essential to correctly predict the motion.
在这里，我们研究了细胞的一个亚群如何能够穿过细胞的聚集物。当群体形成一个幼虫时，我们使用基于随机力的 Dictyostelium discoideum 模型来模拟前胃细胞在不与基质相互作用的情况下可靠地移动到幼虫前端的不同策略，从而忽略了幼虫的整体运动。在所模拟的机制中，定向性更强的前胃细胞是最佳策略，其次是前胃细胞的不对称驱动力增加。细胞黏附分子的寿命虽然不足以产生差异运动，但确实调节了所采用策略的结果。最后，理解和模拟适当的边界条件对于正确预测运动至关重要。
