Minuk G Y
Scand J Infect Dis. 1986;18(5):465-7. doi: 10.3109/00365548609032366.
Gamma-aminobutyric acid (GABA) is a potent amino acid neurotransmitter that suppresses normal neuronal activity in the central nervous system. Recently it has been suggested that GABA may play an important role in the pathogenesis of hepatic encephalopathy. In the present study GABA production by 8 common bacterial pathogens was measured during mid-log, stationary and mid-death phases of growth. All bacteria produced some GABA (range: 160-50 250 pmole/ml) with the majority of GABA production occurring during the mid-death phase of growth. These results suggest that the depressed levels of consciousness seen in patients with overwhelming sepsis or advanced liver disease and extraintestinal infection may in part be secondary to increased bacterial GABA production.
γ-氨基丁酸（GABA）是一种强效氨基酸神经递质，可抑制中枢神经系统中的正常神经元活动。最近有人提出，GABA可能在肝性脑病的发病机制中起重要作用。在本研究中，测定了8种常见细菌病原体在生长的对数中期、稳定期和死亡中期阶段的GABA产量。所有细菌均产生了一些GABA（范围：160 - 50250皮摩尔/毫升），且大部分GABA产生于生长的死亡中期阶段。这些结果表明，在患有严重脓毒症、晚期肝病和肠外感染的患者中出现的意识水平降低，可能部分是由于细菌GABA产量增加所致。
