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与MenoFit相关的意外药物性肝损伤:一种合生元更年期补充剂。

Unexpected Drug-Induced Liver Injury Associated With MenoFit: A Synbiotic Menopause Supplement.

作者信息

Dadlani Apaar, Anudu Azubuogu, Marginean E Celia

机构信息

Section of Gastroenterology and Hepatology, Margaret M. and Albert B. Alkek Department of Medicine, Baylor College of Medicine, Houston, TX.

Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.

出版信息

ACG Case Rep J. 2023 Sep 23;10(9):e01153. doi: 10.14309/crj.0000000000001153. eCollection 2023 Sep.

DOI:10.14309/crj.0000000000001153
PMID:37753097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10519509/
Abstract

MenoFit is a widely available over-the-counter synbiotic supplement, which is marketed for use in relieving menopausal symptoms. So far, there is no published data on liver injury because of its use. We present the first reported case of MenoFit-induced liver injury in a patient who presented with 1 week of jaundice and abnormal liver biochemical tests in the absence of other risk factors and negative comprehensive workup for known etiologies of liver disease.

摘要

MenoFit是一种广泛可得的非处方合生元补充剂,其销售目的是用于缓解更年期症状。到目前为止,尚无因使用该产品导致肝损伤的公开数据。我们报告了首例因MenoFit导致肝损伤的病例,该患者出现黄疸1周且肝脏生化检查异常,不存在其他风险因素,针对已知肝病病因的全面检查结果为阴性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07f3/10519509/a10123f6d645/ac9-10-e01153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07f3/10519509/54a7300a0dfc/ac9-10-e01153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07f3/10519509/a10123f6d645/ac9-10-e01153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07f3/10519509/54a7300a0dfc/ac9-10-e01153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07f3/10519509/a10123f6d645/ac9-10-e01153-g002.jpg

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本文引用的文献

1
Hepatotoxicity due to herbal dietary supplements: Past, present and the future.草药膳食补充剂导致的肝毒性:过去、现在和未来。
Food Chem Toxicol. 2022 Nov;169:113445. doi: 10.1016/j.fct.2022.113445. Epub 2022 Sep 29.
2
AASLD practice guidance on drug, herbal, and dietary supplement-induced liver injury.美国肝病研究学会关于药物、草药和膳食补充剂所致肝损伤的实践指南。
Hepatology. 2023 Mar 1;77(3):1036-1065. doi: 10.1002/hep.32689. Epub 2023 Feb 17.
3
Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review.皮质类固醇在药物性肝损伤中的作用。一项系统评价。
Front Pharmacol. 2022 Feb 10;13:820724. doi: 10.3389/fphar.2022.820724. eCollection 2022.
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Clinical management of patients with drug-induced liver injury (DILI).药物性肝损伤患者的临床管理。
United European Gastroenterol J. 2021 Sep;9(7):781-786. doi: 10.1002/ueg2.12113. Epub 2021 Jun 28.
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Drug induced liver injury: an update.药物性肝损伤:最新进展。
Arch Toxicol. 2020 Oct;94(10):3381-3407. doi: 10.1007/s00204-020-02885-1. Epub 2020 Aug 27.
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Botanicals and Hepatotoxicity.植物药与肝毒性。
Clin Pharmacol Ther. 2018 Sep;104(3):458-469. doi: 10.1002/cpt.1097. Epub 2018 Jun 19.
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Drug-induced Liver Injury: The Hepatic Pathologist's Approach.药物性肝损伤:肝脏病理学家的处理方法
Gastroenterol Clin North Am. 2017 Jun;46(2):273-296. doi: 10.1016/j.gtc.2017.01.004.
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Clinical characteristics of drug-induced liver injury and related risk factors.药物性肝损伤的临床特征及相关危险因素
Exp Ther Med. 2016 Oct;12(4):2606-2616. doi: 10.3892/etm.2016.3627. Epub 2016 Aug 29.