基于角叉菜胶（CRG）和氧化铈纳米颗粒（CeO NPs）的复合海绵支架用于止血应用的研究进展
Development of Composite Sponge Scaffolds Based on Carrageenan (CRG) and Cerium Oxide Nanoparticles (CeO NPs) for Hemostatic Applications.
作者信息
Alizadeh Kimia, Dezvare Yasaman, Kamyab Shirin, Amirian Jhaleh, Brangule Agnese, Bandere Dace
机构信息
Department of Life Science, Faculty of New Sciences and Technologies, University of Tehran, North Kargar Street, Tehran 1439957131, Iran.
Department of Pharmaceutical Chemistry, Riga Stradins University, Dzirciema 16, LV-1007 Riga, Latvia.
出版信息
Biomimetics (Basel). 2023 Sep 4;8(5):409. doi: 10.3390/biomimetics8050409.
In this study, a novel absorbable hemostatic agent was developed using carrageenan (CRG) as a natural polymer and cerium oxide nanoparticles (CeO NPs). CRG-CeO-0.5 and CRG-CeO-1 composites were prepared by compositing CeO to CRG + CeO at a weight ratio of 0.5:100 and 1:100, respectively. The physicochemical and structural properties of these compounds were studied and compared with pristine CRG. Upon incorporation of CeO nanoparticles into the CRG matrix, significant reductions in hydrogel degradation were observed. In addition, it was noted that CRG-CeO exhibited better antibacterial and hemostatic properties than CRG hydrogel without CeO NPs. The biocompatibility of the materials was tested using the NIH 3T3 cell line, and all samples were found to be nontoxic. Particularly, CRG-CeO-1 demonstrated superior hemostatic effects, biocompatibility, and a lower degradation rate since more CeO NPs were present in the CRG matrix. Therefore, CRG-CeO-1 has the potential to be used as a hemostatic agent and wound dressing.
在本研究中，以角叉菜胶（CRG）作为天然聚合物和氧化铈纳米颗粒（CeO NPs）开发了一种新型可吸收止血剂。CRG-CeO-0.5和CRG-CeO-1复合材料分别通过以0.5:100和1:100的重量比将CeO与CRG + CeO复合制备而成。研究了这些化合物的物理化学和结构性质，并与原始CRG进行了比较。将CeO纳米颗粒掺入CRG基质后，观察到水凝胶降解显著降低。此外，值得注意的是，与不含CeO NPs的CRG水凝胶相比，CRG-CeO表现出更好的抗菌和止血性能。使用NIH 3T3细胞系测试了材料的生物相容性，发现所有样品均无毒。特别是，由于CRG基质中存在更多的CeO NPs，CRG-CeO-1表现出优异的止血效果、生物相容性和更低的降解率。因此，CRG-CeO-1有潜力用作止血剂和伤口敷料。
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