Cipolla Clelia, Lazzareschi Ilaria, Curatola Antonietta, Lasorella Claudia, Pane Lucia Celeste, Sessa Linda, Rotunno Giulia, Rigante Donato, Sodero Giorgio
Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito n. 1, 00168 Rome, Italy.
Università Cattolica Sacro Cuore, 00168 Rome, Italy.
Diseases. 2023 Aug 28;11(3):110. doi: 10.3390/diseases11030110.
The aim of this study was to evaluate a potential correlation between results of the oral glucose tolerance test (OGTT) and the auxological/metabolic parameters in a cohort of overweight patients assessed for suspicion of hyperinsulinism. We analyzed 206 patients, comparing those with insulin peak below (nonhyperinsulinemic) and over 100 uIU/mL (hyperinsulinemic) at the OGTT. We found a significant difference in weight ( 0.037), body mass index (BMI, < 0.001) and BMI standard deviations (SD, < 0.001), waist circumference ( = 0.001), hip circumference ( = 0.001), and waist-to-height ratio (WHtR, 0.016) between the two groups. Analyzing the median insulin value during OGTT in the whole population, a weakly positive correlation emerged with weight SD ( < 0.001; = 0.292) and a moderate positive correlation with BMI SD ( < 0.001; = 0.323). We also found a weakly positive correlation with waist circumference ( = 0.001; = 0.214), hip circumference ( 0.001; = 0.217), and WHTR ( 0.016; = 0.209) and a moderate positive correlation with the HOMA index ( < 0.001; = 0.683). The median insulin value correlates with high triglyceride ( < 0.001; 0.266) and triiodothyronine values ( = 0.003; = 0.193) and with low HDL values ( < 0.001; -0.272). In clinical practice the interpretation of laboratory and anthropometric parameters could predict the level of insulin, highlighting also a possible underlying diagnosis of insulin resistance and/or hyperinsulinemia without performing an OGTT.
本研究的目的是评估一组因怀疑高胰岛素血症而接受评估的超重患者口服葡萄糖耐量试验（OGTT）结果与生长发育/代谢参数之间的潜在相关性。我们分析了206例患者，比较了OGTT时胰岛素峰值低于100 uIU/mL（非高胰岛素血症）和高于100 uIU/mL（高胰岛素血症）的患者。我们发现两组在体重（P = 0.037）、体重指数（BMI，P < 0.001）和BMI标准差（SD，P < 0.001）、腰围（P = 0.001）、臀围（P = 0.001）以及腰高比（WHtR，P = 0.016）方面存在显著差异。分析整个人群OGTT期间的胰岛素中位数，发现与体重标准差呈弱正相关（P < 0.001；r = 0.292），与BMI标准差呈中度正相关（P < 0.001；r = 0.323）。我们还发现与腰围呈弱正相关（P = 0.001；r = 0.214）、臀围（P = 0.001；r = 0.217）和WHTR（P = 0.016；r = 0.209），与HOMA指数呈中度正相关（P < 0.001；r = 0.683）。胰岛素中位数与高甘油三酯（P < 0.001；r = 0.266）和三碘甲状腺原氨酸值（P = 0.003；r = 0.193）以及低HDL值（P < 0.001；r = -0.272）相关。在临床实践中，实验室和人体测量参数的解读可以预测胰岛素水平，这也凸显了在不进行OGTT的情况下可能存在的胰岛素抵抗和/或高胰岛素血症的潜在诊断。
