Luo Peili, Shu Lei, Huang Zhengwei, Huang Ying, Wu Chuanbin, Pan Xin, Hu Ping
College of Pharmacy, Jinan University, Guangzhou 511443, China.
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China.
Gels. 2023 Sep 12;9(9):738. doi: 10.3390/gels9090738.
Management of chronic wounds is becoming a serious health problem worldwide. To treat chronic wounds, a suitable healing environment and sustained delivery of growth factors must be guaranteed. Different therapies have been applied for the treatment of chronic wounds such as debridement and photodynamic therapy. Among them, growth factors are widely used therapeutic drugs. However, at present, growth factor delivery systems cannot meet the demand of clinical practice; therefore new methods should be developed to meet the emerging need. For this reason, researchers have tried to modify hydrogels through some methods such as chemical synthesis and molecule modifications to enhance their properties. However, there are still a large number of limitations in practical use like byproduct problems, difficulty to industrialize, and instability of growth factor. Moreover, applications of new materials like lyotropic liquid crystalline (LLC) on chronic wounds have emerged as a new trend. The structure of LLC is endowed with many excellent properties including low cost, ordered structure, and excellent loading efficiency. LLC can provide a moist local environment for the wound, and its lattice structure can embed the growth factors in the water channel. Growth factor is released from the high-concentration carrier to the low-concentration release medium, which can be precisely regulated. Therefore, it can provide sustained and stable delivery of growth factors as well as a suitable healing environment for wounds, which is a promising candidate for chronic wound healing and has a broad prospective application. In conclusion, more reliable and applicable drug delivery systems should be designed and tested to improve the therapy and management of chronic wounds.
慢性伤口的管理正成为全球范围内一个严重的健康问题。为了治疗慢性伤口，必须保证合适的愈合环境和生长因子的持续递送。已经应用了不同的疗法来治疗慢性伤口，如清创术和光动力疗法。其中，生长因子是广泛使用的治疗药物。然而，目前生长因子递送系统无法满足临床实践的需求；因此，应该开发新的方法来满足新出现的需求。出于这个原因，研究人员试图通过化学合成和分子修饰等方法来改性水凝胶，以增强其性能。然而，在实际应用中仍然存在大量限制，如副产物问题、难以工业化以及生长因子的不稳定性。此外，溶致液晶（LLC）等新材料在慢性伤口上的应用已成为一种新趋势。LLC的结构具有许多优异的性能，包括低成本、有序结构和优异的负载效率。LLC可以为伤口提供湿润的局部环境，其晶格结构可以将生长因子嵌入水通道中。生长因子从高浓度载体释放到低浓度释放介质中，这可以精确调节。因此，它可以为伤口提供生长因子的持续稳定递送以及合适的愈合环境，这是慢性伤口愈合的一个有前途的候选者，具有广阔的应用前景。总之，应该设计和测试更可靠、适用的药物递送系统，以改善慢性伤口的治疗和管理。
