Department of Bioengineering, University of Illinois at Urbana-Champaign, 1102 Everitt Lab, 1406 W. Green St., Urbana, Illinois 61801, United States.
Cancer Center at Illinois, Urbana, Illinois 61801, United States.
Mol Pharm. 2023 Jul 3;20(7):3338-3355. doi: 10.1021/acs.molpharmaceut.3c00352. Epub 2023 Jun 20.
Oxygen is a critical factor that can regulate the wound healing processes such as skin cell proliferation, granulation, re-epithelialization, angiogenesis, and tissue regeneration. However, hypoxia, a common occurrence in the wound bed, can impede normal healing processes. To enhance wound healing, oxygenation strategies that could effectively increase wound oxygen levels are effective. The present review summarizes wound healing stages and the role of hypoxia in wound healing and overviews current strategies to incorporate various oxygen delivery or generating materials for wound dressing, including catalase, nanoenzyme, hemoglobin, calcium peroxide, or perfluorocarbon-based materials, in addition to photosynthetic bacteria and hyperbaric oxygen therapy. Mechanism of action, oxygenation efficacy, and potential benefits and drawbacks of these dressings are also discussed. We conclude by highlighting the importance of design optimization in wound dressings to address the clinical needs to improve clinical outcomes.
氧气是一种关键因素，可调节伤口愈合过程，如皮肤细胞增殖、肉芽形成、再上皮化、血管生成和组织再生。然而，在伤口床中常见的缺氧会阻碍正常的愈合过程。为了促进伤口愈合，增加伤口氧气水平的氧合策略是有效的。本综述总结了伤口愈合阶段和缺氧在伤口愈合中的作用，并概述了目前将各种氧输送或产生材料纳入伤口敷料的策略，包括过氧化氢酶、纳米酶、血红蛋白、过氧化钙或全氟碳基材料，以及光合细菌和高压氧治疗。还讨论了这些敷料的作用机制、氧合效果以及潜在的优点和缺点。最后，我们强调了伤口敷料设计优化的重要性，以满足改善临床结果的临床需求。
