Diaconu Alexandra-Diana, Logigan Corina-Lenuta, Peptu Catalina Anisoara, Ibanescu Constanta, Harabagiu Valeria, Peptu Cristian
"Petru Poni" Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iasi, Romania.
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.
Gels. 2023 Sep 16;9(9):755. doi: 10.3390/gels9090755.
Polymer networks based on cyclodextrin and polyethylene glycol were prepared through polyaddition crosslinking using isophorone diisocyanate. The envisaged material properties are the hydrophilic character, specific to PEG and cyclodextrins, and the capacity to encapsulate guest molecules in the cyclodextrin cavity through physical interactions. The cyclodextrin was custom-modified with oligocaprolactone to endow the crosslinked material with a hydrolytically degradable character. SEM, DTG, and FTIR characterization methods have confirmed the morphology and structure of the prepared hydrogels. The influence of the crosslinking reaction feed was investigated through dynamic rheology. Further, thermal water swelling and hydrolytic degradation in basic conditions revealed the connectivity of the polymer network and the particular influence of the cyclodextrin amount in the crosslinking reaction feed on the material properties. Also, levofloxacin was employed as a model drug to investigate the drug loading and release capacity of the prepared hydrogels.
基于环糊精和聚乙二醇的聚合物网络通过使用异佛尔酮二异氰酸酯的加成交联反应制备而成。预期的材料特性包括聚乙二醇和环糊精特有的亲水性，以及通过物理相互作用在环糊精腔内包封客体分子的能力。环糊精用低聚己内酯进行了定制改性，以使交联材料具有可水解降解的特性。扫描电子显微镜（SEM）、差示热重分析（DTG）和傅里叶变换红外光谱（FTIR）表征方法证实了所制备水凝胶的形态和结构。通过动态流变学研究了交联反应进料的影响。此外，在碱性条件下的热水溶胀和水解降解揭示了聚合物网络的连通性以及交联反应进料中环糊精用量对材料性能的特殊影响。此外，左氧氟沙星被用作模型药物来研究所制备水凝胶的载药和释药能力。
