Al Maruf D S Abdullah, Ghosh Yohaann Ali, Xin Hai, Cheng Kai, Mukherjee Payal, Crook Jeremy Micah, Wallace Gordon George, Klein Travis Jacob, Clark Jonathan Robert
Integrated Prosthetics and Reconstruction, Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Camperdown 2050, Australia.
Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Camperdown 2050, Australia.
Polymers (Basel). 2022 Oct 5;14(19):4186. doi: 10.3390/polym14194186.
Free flap surgery is currently the only successful method used by surgeons to reconstruct critical-sized defects of the jaw, and is commonly used in patients who have had bony lesions excised due to oral cancer, trauma, infection or necrosis. However, donor site morbidity remains a significant flaw of this strategy. Various biomaterials have been under investigation in search of a suitable alternative for segmental mandibular defect reconstruction. Hydrogels are group of biomaterials that have shown their potential in various tissue engineering applications, including bone regeneration, both through in vitro and in vivo pre-clinical animal trials. This review discusses different types of hydrogels, their fabrication techniques, 3D printing, their potential for bone regeneration, outcomes, and the limitations of various hydrogels in preclinical models for bone tissue engineering. This review also proposes a modified technique utilizing the potential of hydrogels combined with scaffolds and cells for efficient reconstruction of mandibular segmental defects.
游离皮瓣手术是目前外科医生用于修复颌骨临界尺寸缺损的唯一成功方法，常用于因口腔癌、创伤、感染或坏死而切除骨病变的患者。然而，供区并发症仍然是该策略的一个重大缺陷。为寻找节段性下颌骨缺损重建的合适替代方案，人们一直在研究各种生物材料。水凝胶是一类生物材料，通过体外和体内临床前动物试验，已在包括骨再生在内的各种组织工程应用中显示出其潜力。本文综述讨论了不同类型的水凝胶、其制备技术、3D打印、其骨再生潜力、结果以及各种水凝胶在骨组织工程临床前模型中的局限性。本文综述还提出了一种改良技术，利用水凝胶与支架和细胞相结合的潜力，以有效重建下颌节段性缺损。
