Nantong Key Laboratory of Public Health and Medical Analysis, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, PR China.
Nantong Key Laboratory of Public Health and Medical Analysis, School of Public Health, Nantong University, Nantong, Jiangsu, 226019, PR China.
Talanta. 2024 Jan 15;267:125237. doi: 10.1016/j.talanta.2023.125237. Epub 2023 Sep 24.
To detect a range of trace biomarkers associated with human diseases, researchers have been focusing on developing biosensors that possess high sensitivity and specificity. Electrochemiluminescence (ECL) biosensors have emerged as a prominent research tool in recent years, owing to their potential superiority in low background signal, high sensitivity, straightforward instrumentation, and ease of operation. Functional nanomaterials (FNMs) exhibit distinct advantages in optimizing electrical conductivity, increasing reaction rate, and expanding specific surface area due to their small size effect, quantum size effect, and surface and interface effects, which can significantly improve the stability, reproducibility, and sensitivity of the biosensors. Thereby, various nanomaterials (NMs) with excellent properties have been developed to construct efficient ECL biosensors. This review provides a detailed summary and discussion of FNMs-based ECL biosensors and their applications in cancer biomarkers detection.
为了检测与人类疾病相关的一系列痕量生物标志物，研究人员一直致力于开发具有高灵敏度和特异性的生物传感器。近年来，电致化学发光（ECL）生物传感器因其具有低背景信号、高灵敏度、仪器简单和操作方便等潜在优势，已成为一种重要的研究工具。功能纳米材料（FNMs）由于具有小尺寸效应、量子尺寸效应和表面及界面效应，在优化导电性、提高反应速率和扩大比表面积方面表现出明显的优势，这可以显著提高生物传感器的稳定性、重现性和灵敏度。因此，已经开发出各种具有优异性能的纳米材料（NMs）来构建高效的 ECL 生物传感器。本综述详细总结和讨论了基于 FNMs 的 ECL 生物传感器及其在癌症生物标志物检测中的应用。
