氟化物涂料中添加纳米级三聚磷酸钠可减少体外釉质的腐蚀性磨损。
Fluoride varnishes supplemented with nano-sized sodium trimetaphosphate reduce enamel erosive wear in vitro.
机构信息
Department of Preventive and Restorative Dentistry, School of Dentistry, São Paulo State University (UNESP), José Bonifácio 1193, Araçatuba, SP 16015-050, Brazil.
Department of Preventive Dentistry, Periodontology and Cariology, University Medical Center Göttingen, Göttingen, Germany.
出版信息
J Dent. 2023 Nov;138:104726. doi: 10.1016/j.jdent.2023.104726. Epub 2023 Sep 25.
OBJECTIVE
To evaluate the effect of fluoride (F) varnishes with sodium trimetaphosphate (TMP) on erosive tooth wear (ETW) in vitro.
METHODS
Enamel blocks (n = 100) were divided into 5 experimental groups (n = 20/group): Placebo (Pla - without F/TMP); 5 % NaF (NaF); 5 % NaF + 5 % micrometric TMP (NaF+5 %MICRO); 5 % NaF + 2.5 % nano-sized TMP (NaF+2.5 %NANO), and 5 % NaF + 5 % nano-sized TMP (NaF+5 %NANO). Blocks received a single varnish application (6 h contact), and were submitted to 4 daily erosive challenges (ERO, 0.05 M citric acid, pH 3.2, 90 s, under agitation), for 5 days. After ERO, half of the blocks (n = 10/group) were subjected to brushing abrasion (ERO+ABR). Profilometry, surface hardness (SH), and cross-sectional hardness (ΔKHN) were determined. The data were submitted to 2-way ANOVA and Fisher's LSD test (p < 0.05).
RESULTS
Enamel wear was significantly lower for ERO compared with ERO+ABR for all varnishes tested (p < 0.001), following the pattern NaF+5 %NANO < NaF+5 %MICRO < NaF < NaF+2.5 %NANO < Pla (both for ERO and ERO+ABR). The highest SH loss was observed for Pla and the lowest for NaF (ERO) and NaF+2.5 %NANO (ERO+ABR), without significant differences among NaF+2.5 %NANO, NaF, and NaF+5 %MICRO. The highest ΔKHN values were observed for NaF+5 %MICRO and NaF+5 %NANO at 5-30 µm, with less marked differences among the groups at 30-70 µm (ERO and ERO+ABR).
CONCLUSIONS
The addition of TMP to F varnishes significantly improves protection against ETW in vitro. The use of 5 % nano-sized TMP further enhances such effects.
CLINICAL SIGNIFICANCE
F varnishes containing TMP can reduce enamel loss caused by ERO or ERO+ABR.
目的
评估含有三聚磷酸钠（TMP）的氟化物（F）涂料对侵蚀性牙齿磨损（ETW）的影响。
方法
将 100 个牙釉质块分为 5 个实验组（每组 20 个）：对照组（不含有 F/TMP 的 Pla）；5% NaF（NaF）；5% NaF+5% 微米级 TMP（NaF+5%MICRO）；5% NaF+2.5% 纳米级 TMP（NaF+2.5%NANO），以及 5% NaF+5% 纳米级 TMP（NaF+5%NANO）。各块接受单次涂覆（6 小时接触），然后进行 4 次每日侵蚀性挑战（ERO，0.05 M 柠檬酸，pH 值 3.2，90 s，搅拌），持续 5 天。在 ERO 之后，一半的块（每组 10 个）进行刷牙磨损（ERO+ABR）。通过轮廓仪、表面硬度（SH）和横截面硬度（ΔKHN）进行测量。将数据提交给双因素方差分析和 Fisher's LSD 检验（p<0.05）。
结果
与 ERO+ABR 相比，所有测试的涂料在 ERO 时的牙釉质磨损明显更低（p<0.001），模式为 NaF+5%NANO<NaF+5%MICRO<NaF<NaF+2.5%NANO<Pla（无论是在 ERO 还是 ERO+ABR 时）。Pla 的 SH 损失最大，NaF 最小（ERO），NaF+2.5%NANO 最小（ERO+ABR），而 NaF+2.5%NANO、NaF 和 NaF+5%MICRO 之间没有显著差异。在 5-30 μm 时，NaF+5%MICRO 和 NaF+5%NANO 的 ΔKHN 值最高，而在 30-70 μm 时，各组之间的差异不那么明显（ERO 和 ERO+ABR）。
结论
TMP 对 F 涂料的添加显著提高了体外对 ETW 的保护作用。使用 5%纳米级 TMP 可进一步增强这种效果。
临床意义
含有 TMP 的 F 涂料可减少 ERO 或 ERO+ABR 引起的牙釉质丧失。
Zotero 插件