Manarelli Michele Maurício, Moretto Marcelo Juliano, Sassaki Kikue Takebayashi, Martinhon Cleide Cristina Rodrigues, Pessan Juliano Pelim, Delbem Alberto Carlos Botazzo
Am J Dent. 2013 Dec;26(6):307-12.
To assess in vitro the effect on enamel erosion (ERO) and erosion followed by abrasion (ERO+ABR) of varnishes with different fluoride concentrations, supplemented or not with sodium trimetaphosphate (TMP).
Bovine enamel blocks were randomly divided into six groups according to the type of varnish used: placebo (no F), NaF 5%, NaF 2.5%, NaF 2.5% plus TMP 3.5%, NaF 2.5% plus TMP 5%, NaF 2.5% plus TMP 10%. Varnishes were tested for ERO and ERO+ABR, separately for 3 and 5 days. ERO was done by immersion in Sprite Zero (5 minutes, 4x/day), while ERO+ABR was performed by brushing for 15 seconds after each erosive challenge. Enamel wear (microm) and cross-sectional hardness (AKHN) were assessed after the experimental periods. Data were analyzed by ANOVA, Tukey's test and Pearson's correlation coefficient (P< 0.05).
Varnishes supplemented with TMP promoted significantly lower wear and hardness loss when compared to the other treatments in all conditions studied (P< 0.05). Similar wear rates were observed for the placebo, NaF 2.5% and NaF 5% varnishes (P> 0.05). Greater wear was observed after 5 days of ERO and ERO+ABR when compared with 3 days (P< 0.05). Positive and significant correlations were found between enamel wear and AKHN. No dose-response relationship was found between TMP concentration and wear and hardness. It was concluded that fluoride varnishes supplemented with TMP had a higher protective effect against ERO and ERO+ABR, which was associated with a reduction in enamel softening.
在体外评估不同氟浓度、添加或不添加三聚磷酸钠（TMP）的清漆对牙釉质侵蚀（ERO）以及侵蚀后磨损（ERO+ABR）的影响。
根据所用清漆类型，将牛牙釉质块随机分为六组：安慰剂组（无氟）、5%氟化钠组、2.5%氟化钠组、2.5%氟化钠+3.5% TMP组、2.5%氟化钠+5% TMP组、2.5%氟化钠+10% TMP组。分别对清漆进行3天和5天的ERO及ERO+ABR测试。ERO通过浸泡在零度雪碧中（5分钟，每天4次）进行，而ERO+ABR则在每次侵蚀挑战后刷牙15秒。在实验期结束后评估牙釉质磨损（微米）和横截面硬度（AKHN）。数据通过方差分析、Tukey检验和Pearson相关系数进行分析（P<0.05）。
在所有研究条件下，与其他处理相比，添加TMP的清漆磨损和硬度损失显著更低（P<0.05）。安慰剂组、2.5%氟化钠组和5%氟化钠组清漆的磨损率相似（P>0.05）。与3天相比，ERO和ERO+ABR 5天后观察到更大的磨损（P<0.05）。牙釉质磨损与AKHN之间存在正相关且显著相关。未发现TMP浓度与磨损及硬度之间存在剂量反应关系。得出结论，添加TMP的氟化物清漆对ERO和ERO+ABR具有更高的保护作用，这与牙釉质软化的减少有关。
