Silva Isabela Ferreira da, Capalbo Letícia Cabrera, Dal-Fabbro Renan, Paiva Mayra Frasson, Hosida Thayse Yumi, Báez-Quintero Liliana Carolina, Sampaio Caio, Monteiro Douglas Roberto, Delbem Alberto Carlos Botazzo, Pessan Juliano Pelim
Universidade Estadual Paulista - Unesp, School of Dentistry of Araçatuba, Department of Preventive and Restorative Dentistry, Araçatuba, SP, Brazil.
University of Michigan, School of Dentistry, Department of Cariology, Restorative Sciences, and Endodontics, Ann Arbor, MI, USA.
Braz Oral Res. 2024 Jul 12;38:e056. doi: 10.1590/1807-3107bor-2024.vol38.0056. eCollection 2024.
This study evaluated the effect of fluoride varnishes containing micrometric or nanosized sodium trimetaphosphate (TMP) on dentin erosive wear in vitro. Bovine root dentin blocks were selected by surface hardness and randomly divided into five experimental groups/varnishes (n = 20/group): placebo, 5% sodium fluoride (NaF); 5% NaF+5% micrometric TMP; 5% NaF+2.5% nanosized TMP; and 5% NaF+5% nanosized TMP. Half of the surface of all blocks received a single application of the assigned varnish, with subsequent immersion in artificial saliva for 6 h. Varnishes were then removed and the blocks were immersed in citric acid (90 s, 4×/day, 5 days). After each erosive cycle, ten blocks of each group were immersed in a placebo dentifrice for 15 s (ERO), while the other ten blocks were subjected to abrasion by brushing (ERO+ABR). Dentin erosive wear was assessed by profilometry. Data were submitted to 2-way ANOVA and to the Holm-Sidak test (p<0.05). Dentin erosive wear was significantly higher for ERO+ABR than for ERO for all varnishes. TMP-containing varnishes promoted superior effects against dentin erosive wear compared with 5% NaF alone; and 5% nanosized TMP led to the lowest wear among all varnishes. In conclusion, the addition of TMP to conventional fluoride varnish (i.e., varnish containing only NaF) enhanced its protective effects against bovine root dentin erosion and erosion+abrasion. Additionally, the use of 5% nanosized TMP led to superior effects in comparison to 5% micrometric TMP, both for erosion and erosion+abrasion in vitro.
本研究评估了含有微米级或纳米级三聚偏磷酸钠（TMP）的含氟涂料对体外牙本质侵蚀性磨损的影响。通过表面硬度选择牛牙根牙本质块，并随机分为五个实验组/涂料（每组n = 20）：安慰剂、5%氟化钠（NaF）；5% NaF + 5%微米级TMP；5% NaF + 2.5%纳米级TMP；以及5% NaF + 5%纳米级TMP。所有牙本质块表面的一半接受指定涂料的单次涂抹，随后浸泡在人工唾液中6小时。然后去除涂料，将牙本质块浸泡在柠檬酸中（90秒，每天4次，共5天）。在每个侵蚀周期后，每组的10个牙本质块浸泡在安慰剂牙膏中15秒（ERO），而另外10个牙本质块通过刷牙进行磨损（ERO + ABR）。通过轮廓测定法评估牙本质侵蚀性磨损。数据进行双向方差分析和霍尔姆 - 西达克检验（p<0.05）。对于所有涂料，ERO + ABR组的牙本质侵蚀性磨损明显高于ERO组。与单独使用5% NaF相比，含TMP的涂料对牙本质侵蚀性磨损具有更好的防护效果；并且在所有涂料中，5%纳米级TMP导致的磨损最低。总之，在传统含氟涂料（即仅含NaF的涂料）中添加TMP可增强其对牛牙根牙本质侵蚀和侵蚀 + 磨损的防护效果。此外，在体外，对于侵蚀和侵蚀 + 磨损，使用5%纳米级TMP比5%微米级TMP具有更好的效果。
