Shanxi Provincial Key Laboratory of Medical Molecular Cell Biology, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institutes of Biomedical Sciences, Shanxi University, No. 92 Wucheng Road, Taiyuan 030006, China.
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.
Cells. 2023 Sep 5;12(18):2212. doi: 10.3390/cells12182212.
Autophagy is the major lysosomal pathway for the clearance of proteins, organelles and microbes in eukaryotic cells. Therefore, autophagic dysfunction can lead to numerous human diseases, like cancer or neurodegeneration, and may facilitate infections by pathogens. However, despite tremendous advances in the understanding of autophagy over the past decades, the functions and regulations of autophagy-related proteins in canonical and non-canonical autophagy are still not fully resolved. The Special Issue "Model Organisms to Study Autophagy" organized by includes six original articles and one review that show the latest achievements in autophagy research using different model organisms. The Special Issue summarizes and discusses different aspects of autophagy that open new avenues in understanding autophagy functions and mechanisms.
自噬是真核细胞中清除蛋白质、细胞器和微生物的主要溶酶体途径。因此，自噬功能障碍可导致许多人类疾病，如癌症或神经退行性疾病，并可能促进病原体的感染。然而，尽管在过去几十年中对自噬的理解取得了巨大进展，但自噬相关蛋白在经典和非经典自噬中的功能和调节仍未完全解决。本专题由[作者 1]组织，包括 6 篇原始文章和 1 篇综述，展示了使用不同模式生物研究自噬的最新成果。本专题总结和讨论了自噬的不同方面，为理解自噬功能和机制开辟了新途径。
