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全身性杀虫剂犬类治疗对热带地区恰加斯病控制的有效性。

Effectiveness of Systemic Insecticide Dog Treatment for the Control of Chagas Disease in the Tropics.

作者信息

Fiatsonu Edem, Deka Aniruddha, Ndeffo-Mbah Martial L

机构信息

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77845, USA.

Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX 77845, USA.

出版信息

Biology (Basel). 2023 Sep 13;12(9):1235. doi: 10.3390/biology12091235.

DOI:10.3390/biology12091235
PMID:37759635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10525078/
Abstract

Chagas disease, caused by and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomines. Here, we assessed the impact of dog treatment on transmission. We developed a mathematical model of transmission among triatomines, dogs, humans, and rodents. We used the model to evaluate the impact of dog treatment regimens on transmission dynamics to determine their effectiveness in reducing infection among hosts. We show that a 3-month treatment regimen may reduce incidence among humans by 59-80% in a high transmission setting, and 26-82% in a low transmission setting. An annual treatment may reduce incidence among humans by 49-74% in a high transmission setting, and by 11-76% in a low transmission setting. However, dog treatment may substantially increase prevalence among dogs if dog consumption of dead triatomines increases. Our model indicates that dog treatment may reduce infections among humans, but it may increase infections in dogs. Therefore, a holistic approach targeting different hosts is necessary for Chagas elimination.

摘要

恰加斯病由锥蝽引起并通过锥蝽传播，可导致许多哺乳动物出现严重心脏问题并死亡。最近的研究表明，对犬类进行全身杀虫剂处理在杀死锥蝽方面非常有效。在此，我们评估了对犬类的处理对[病原体名称未给出]传播的影响。我们建立了一个关于锥蝽、犬类、人类和啮齿动物之间[病原体名称未给出]传播的数学模型。我们使用该模型评估犬类处理方案对[病原体名称未给出]传播动态的影响，以确定它们在降低宿主间[病原体名称未给出]感染方面的有效性。我们表明，在高传播环境中，为期3个月的处理方案可使人类中的[病原体名称未给出]发病率降低59% - 80%，在低传播环境中降低26% - 82%。每年进行一次处理在高传播环境中可使人类发病率降低49% - 74%，在低传播环境中降低11% - 76%。然而，如果犬类食用死亡锥蝽的情况增加，对犬类的处理可能会大幅增加犬类中的[病原体名称未给出]患病率。我们的模型表明，对犬类的处理可能会减少人类中的[病原体名称未给出]感染，但可能会增加犬类中的感染。因此，对于消除恰加斯病，需要一种针对不同宿主的整体方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/cd68b34ecd64/biology-12-01235-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/b08b3af1fa72/biology-12-01235-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/8881303a846e/biology-12-01235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/46b4b679c223/biology-12-01235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/8fc8107f401f/biology-12-01235-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/1f54457e502c/biology-12-01235-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/cd68b34ecd64/biology-12-01235-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/b08b3af1fa72/biology-12-01235-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/28095e0d59cc/biology-12-01235-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/8881303a846e/biology-12-01235-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/46b4b679c223/biology-12-01235-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/8fc8107f401f/biology-12-01235-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/1f54457e502c/biology-12-01235-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a6/10525078/cd68b34ecd64/biology-12-01235-g007.jpg

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