Cortese-Krott Miriam M
Myocardial Infarction Research Laboratory, Department of Cardiology, Pulmonology and Angiology, Medical Faculty, Heinrich-Heine-University, Universitätstrasse 1, 40225 Düsseldorf, Germany.
Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
Antioxidants (Basel). 2023 Sep 7;12(9):1736. doi: 10.3390/antiox12091736.
Beyond their established role as oxygen carriers, red blood cells have recently been found to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant cells. Emerging evidence indicates that reactive species derived from the metabolism of O, NO, and HS can interact with each other, potentially influencing common biological targets. These interactions have been encompassed in the concept of the This review explores the potential application of the concept of to understand the redox physiology of RBCs. It specifically examines how are generated and detoxified, their interactions with each other, and their targets. Hemoglobin is a key player in the within RBCs, given its abundance and fundamental role in O/CO exchange, NO transport/metabolism, and sulfur species binding/production. Future research should focus on understanding how modulation of the may regulate RBC biology, physiology, and their systemic effects.
除了作为氧载体的既定作用外，最近发现红细胞有助于全身一氧化氮（NO）和硫化物代谢，并作为强大的循环抗氧化细胞发挥作用。新出现的证据表明，源自氧（O）、NO和硫化氢（HS）代谢的活性物质可以相互作用，可能影响共同的生物学靶点。这些相互作用已被纳入“[具体概念名称未给出]”的概念中。本综述探讨了“[具体概念名称未给出]”概念在理解红细胞氧化还原生理学方面的潜在应用。它具体研究了“[相关物质未明确]”是如何产生和解毒的，它们之间的相互作用以及它们的靶点。鉴于血红蛋白在红细胞内的丰富程度及其在氧/二氧化碳交换、NO运输/代谢以及硫物种结合/产生中的基本作用，它是红细胞内“[具体概念内容未明确]”的关键参与者。未来的研究应专注于了解“[具体概念内容未明确]”的调节如何可能调节红细胞生物学、生理学及其全身效应。
