The Reactive Species Interactome in Red Blood Cells: Oxidants, Antioxidants, and Molecular Targets.

Beyond their established role as oxygen carriers, red blood cells have recently been found to contribute to systemic NO and sulfide metabolism and act as potent circulating antioxidant cells. Emerging evidence indicates that reactive species derived from the metabolism of O, NO, and HS can interact with each other, potentially influencing common biological targets. These interactions have been encompassed in the concept of the This review explores the potential application of the concept of to understand the redox physiology of RBCs. It specifically examines how are generated and detoxified, their interactions with each other, and their targets. Hemoglobin is a key player in the within RBCs, given its abundance and fundamental role in O/CO exchange, NO transport/metabolism, and sulfur species binding/production. Future research should focus on understanding how modulation of the may regulate RBC biology, physiology, and their systemic effects.