Clar-Marmaneu Helena, García-Fernández Alba Estela, García-Fernández Francisco Javier
Facultad de Farmacia, Universitat de València, 46100 Burjassot, Spain.
Informática Médico Farmaceútica, 46021 Valencia, Spain.
Cancers (Basel). 2023 Sep 12;15(18):4520. doi: 10.3390/cancers15184520.
In the landscape of colorectal cancer treatment, classical chemotherapeutic agents such as 5-fluorouracil, capecitabine, irinotecan, oxaliplatin, trifluridine, and tipiracil have historically played a pivotal role. This study presents a comprehensive bibliometric analysis of the top 100 most influential articles focusing on these classic chemotherapy drugs in the management of colorectal cancer. With this, we shed light on their current importance, despite the emergence of new therapeutic targets and treatments in the field of oncology. Systematically evaluating research outputs, this analysis reveals a prevalence of co-authorship among institutions, countries (led by the United States, China, and Europe), and researchers highlighting the global and collaborative nature of efforts in research, utilization, and development of these drugs. Three thematic axes lead the research: pharmacogenetics, the development of new pharmaceutical forms, and the use of adjuvants. This research serves as a foundation for future endeavors, aiding researchers, clinicians, and policymakers in making informed decisions about the direction of research and development in the dynamic field of colorectal cancer therapy.
在结直肠癌治疗领域，传统化疗药物如5-氟尿嘧啶、卡培他滨、伊立替康、奥沙利铂、曲氟尿苷和替匹嘧啶一直发挥着关键作用。本研究对100篇最具影响力的文章进行了全面的文献计量分析，这些文章聚焦于这些经典化疗药物在结直肠癌治疗中的应用。借此，我们阐明了它们当前的重要性，尽管肿瘤学领域出现了新的治疗靶点和治疗方法。通过系统评估研究成果，该分析揭示了机构、国家（以美国、中国和欧洲为首）和研究人员之间的合作情况，突显了在这些药物的研究、应用和开发方面全球协作的性质。三个主题轴引领着研究方向：药物遗传学、新型药物剂型的开发以及佐剂的使用。这项研究为未来的努力奠定了基础，有助于研究人员、临床医生和政策制定者在结直肠癌治疗这一动态领域中，就研发方向做出明智决策。
