Sivamaruthi Bhagavathi Sundaram, Raghani Neha, Chorawala Mehul, Bhattacharya Sankha, Prajapati Bhupendra G, Elossaily Gehan M, Chaiyasut Chaiyavat
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Biomedicines. 2023 Sep 21;11(9):2587. doi: 10.3390/biomedicines11092587.
The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer's disease (AD). The involvement of the NF-κB pathway in immune system responses, inflammation, oxidative stress, and neuronal survival highlights its significance in AD progression. We discuss the advantages of NF-κB pathway inhibition, including the potential to mitigate neuroinflammation, modulate amyloid beta (Aβ) production, and promote neuronal survival. However, we also acknowledge the limitations and challenges associated with this approach. Balancing the fine line between dampening inflammation and preserving physiological immune responses is critical to avoid unintended consequences. This review combines current knowledge on the NF-κB pathway's intricate involvement in AD pathogenesis, emphasizing its potential as a therapeutic target. By evaluating both advantages and limitations, we provide a holistic view of the feasibility and challenges of NF-κB pathway modulation in AD treatment. As the quest for effective AD therapies continues, an in-depth understanding of the NF-κB pathway's multifaceted roles will guide the development of targeted interventions with the potential to improve AD management.
核因子κB（NF-κB）信号通路已成为包括阿尔茨海默病（AD）等神经退行性疾病发病机制中的关键因素。NF-κB信号通路参与免疫系统反应、炎症、氧化应激和神经元存活，凸显了其在AD进展中的重要性。我们讨论了抑制NF-κB信号通路的优势，包括减轻神经炎症、调节β-淀粉样蛋白（Aβ）生成以及促进神经元存活的潜力。然而，我们也认识到这种方法存在的局限性和挑战。在减轻炎症和维持生理免疫反应之间找到平衡对于避免意外后果至关重要。本综述结合了当前关于NF-κB信号通路在AD发病机制中复杂作用的知识，强调了其作为治疗靶点的潜力。通过评估优势和局限性，我们全面审视了在AD治疗中调节NF-κB信号通路的可行性和挑战。随着对有效AD治疗方法的探索不断深入，深入了解NF-κB信号通路的多方面作用将指导有潜力改善AD治疗的靶向干预措施的开发。
