Šetinc Maja, Zajc Petranović Matea, Slivšek Goran, Mijač Sandra, Celinščak Željka, Stojanović Marković Anita, Bišof Vesna, Peričić Salihović Marijana, Škarić-Jurić Tatjana
Institute for Anthropological Research, 10000 Zagreb, Croatia.
Faculty of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Genes (Basel). 2023 Sep 15;14(9):1806. doi: 10.3390/genes14091806.
Some sources report a connection of cellular senescence with chronic pathological conditions; however, the association between particular cellular processes and general health is rarely examined. This study aims to test the relationship of general health with DNA damage pathways that play a crucial role in senescence. The association of ten selected SNPs with subjective and objective general health and functional ability indicators has been tested in 314 oldest-old people from Croatia. Multivariate logistic regression was employed to simultaneously test the impact of variables potentially influencing targeted health and functional ability variables. The best model, explaining 37.1% of the variance, has six independent significant predictors of functional ability scores: rs16847897 in , rs533984 in , and rs4977756 in , chronic disease count, Mini-Mental State Examination scores, and age at surveying. In conclusion, the examined ten loci involved in DNA damage repair pathways showed a more significant association with self-rated health and functional ability than with the number of disease or prescribed medicaments. The more frequent, longevity-related homozygote (GG) in rs16847897 was associated with all three aspects of self-assessments-health, mobility, and independence-indicating that this locus might have a true impact on the overall vitality of the oldest-old persons.
一些资料报道了细胞衰老与慢性病理状况之间的联系；然而，特定细胞过程与总体健康之间的关联很少被研究。本研究旨在测试在衰老过程中起关键作用的DNA损伤途径与总体健康之间的关系。在来自克罗地亚的314名高龄老人中，测试了10个选定的单核苷酸多态性（SNP）与主观和客观总体健康及功能能力指标之间的关联。采用多变量逻辑回归同时测试可能影响目标健康和功能能力变量的因素的影响。解释37.1%方差的最佳模型有6个功能能力得分的独立显著预测因子：位于[具体位置1]的rs16847897、位于[具体位置2]的rs533984、位于[具体位置3]的rs4977756、慢性病计数、简易精神状态检查表得分以及调查时的年龄。总之，所研究的参与DNA损伤修复途径的10个基因座与自我评定的健康和功能能力的关联比与疾病数量或所开药物的关联更为显著。rs16847897中更常见的、与长寿相关的纯合子（GG）与自我评估的三个方面——健康、活动能力和独立性——相关，表明该基因座可能对高龄老人的整体活力有真正影响。
