Świtała Jacek, Sycińska-Dziarnowska Magdalena, Spagnuolo Gianrico, Woźniak Krzysztof, Mańkowska Katarzyna, Szyszka-Sommerfeld Liliana
Department of Orthodontics, Pomeranian Medical University in Szczecin, Al. Powst. Wlkp. 72, 70111 Szczecin, Poland.
Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80131 Napoli, Italy.
J Clin Med. 2023 Sep 9;12(18):5867. doi: 10.3390/jcm12185867.
Cleft in the lip and/or palate (CLP) is a congenital facial deformity that significantly impacts the oral cavity's structure and function. This malformation can affect the oral microbiota. The objective of this systematic review was to examine and consolidate the current scientific evidence on the oral microflora in children with CLP.
The search strategy included the PubMed, PubMed Central, Web of Science, Scopus, and Embase databases. The inclusion criteria were studies assessing oral microbiota in children with CLP. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the included studies.
The search strategy identified 422 potential articles. Twelve papers met the inclusion criteria. High heterogeneity was observed in methodologies, sample sites, and patient characteristics. Eight studies assessed the levels of and in saliva, with some reporting significantly higher levels in the cleft group compared to controls, while others found no differences. One study reported a significantly higher colonization rate of species in patients with cleft lip and/or palate.
The results of the available studies are unclear. Further research is needed to gain a comprehensive understanding of the oral microbiota and potential implications for oral health management in this population. The review was not registered Registration Statement.
唇腭裂（CLP）是一种先天性面部畸形，会严重影响口腔的结构和功能。这种畸形会影响口腔微生物群。本系统评价的目的是检查和整合目前关于唇腭裂儿童口腔微生物群的科学证据。
检索策略包括PubMed、PubMed Central、Web of Science、Scopus和Embase数据库。纳入标准为评估唇腭裂儿童口腔微生物群的研究。采用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。
检索策略共识别出422篇潜在文章。12篇论文符合纳入标准。在方法、样本部位和患者特征方面观察到高度异质性。8项研究评估了唾液中[具体物质1]和[具体物质2]的水平，一些研究报告腭裂组的水平显著高于对照组，而另一些研究则未发现差异。一项研究报告唇裂和/或腭裂患者中[某物种]的定植率显著更高。
现有研究结果尚不清楚。需要进一步研究以全面了解该人群的口腔微生物群及其对口腔健康管理的潜在影响。本综述未注册注册声明。
