择期全膝关节置换术中维生素C与炎性细胞因子水平
Vitamin C and inflammatory cytokine levels in elective total knee arthroplasty.
作者信息
Shah Shalin, Brown Christopher, Owen John, Fisher Bernard, Natarajan Ramesh, Kates Stephen
机构信息
Virginia Commonwealth University School of Medicine, McGlothlin Medical Education Center (MMEC), USA.
Orthopaedic Research Laboratory, Virginia Commonwealth University, USA.
出版信息
Nutr Health. 2020 Jun;26(2):87-91. doi: 10.1177/0260106020910632. Epub 2020 Mar 30.
BACKGROUND
Vitamin C levels are decreased in arthritis patients and reduced levels following surgery may impair adequate healing.
AIM
This study measured changes in vitamin C and inflammatory markers in patients undergoing total knee arthroplasty (TKA).
METHODS
Venous blood samples were collected from 10 patients during the preoperative to postoperative period. Vitamin C, interleukin-1, interleukin-6 (IL-6), and C-reactive protein (CRP) levels were measured using various assays.
RESULTS
No significant changes in vitamin C levels were measured. However, all participants had suboptimal preoperative vitamin C levels and 90% had suboptimal levels postoperatively. IL-6 and CRP levels significantly increased during the immediate postoerative period.
CONCLUSION
There was a rise in inflammation following TKA while vitamin C levels did not significantly change during this short study period. Of note, every patient had suboptimal vitamin C levels prior to surgery and 90% continued with suboptimal levels two days postoperatively.
背景
关节炎患者体内维生素C水平降低，术后水平降低可能会影响伤口充分愈合。
目的
本研究测量了接受全膝关节置换术（TKA）患者的维生素C和炎症标志物的变化。
方法
在术前至术后期间从10名患者采集静脉血样。使用各种检测方法测量维生素C、白细胞介素-1、白细胞介素-6（IL-6）和C反应蛋白（CRP）水平。
结果
未检测到维生素C水平有显著变化。然而，所有参与者术前维生素C水平均未达最佳，90%的参与者术后维生素C水平也未达最佳。术后即刻IL-6和CRP水平显著升高。
结论
TKA后炎症有所增加，而在这个短期研究期间维生素C水平没有显著变化。值得注意的是，每位患者术前维生素C水平均未达最佳，90%的患者术后两天维生素C水平仍未达最佳。
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