基于培养分析的真菌性与非真菌性鼻窦炎比较

Comparison of Fungal and Non-Fungal Rhinosinusitis by Culture-Based Analysis.

作者信息

Cha Chih-Hung, Chen Wei-Chih, Wang Yu-Ming, Wu Shao-Chun, Chiu Tai-Jan, Wu Ching-Nung, Wee Yinshen, Wang Ching-Shuen, Yang Yao-Hsu, Luo Sheng-Dean

机构信息

Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

Department of Radiation Oncology and Proton & Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

出版信息

J Pers Med. 2023 Sep 11;13(9):1368. doi: 10.3390/jpm13091368.

DOI:10.3390/jpm13091368

PMID:37763136

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10532977/

Abstract

BACKGROUND

Incidence of fungal rhinosinusitis has increased in recent few years. We investigated the differences in microbiological findings between patients with fungal and non-fungal rhinosinusitis by growing microbiological cultures from samples obtained from sinus surgery.

METHODS

Using the Chang Gung Research Database, we enrolled all chronic rhinosinusitis (CRS) patients who had ever undergone sinus surgery from 2001 to 2019 and had microbiological culture during sinus surgery. Enrolled patients were divided into fungal and non-fungal groups, based on fungal culture and surgical pathology.

RESULTS

A total of 898 patients were diagnosed with fungal rhinosinusitis and 2884 with non-fungal rhinosinusitis. The fungal group had a higher age distribution (56.9 ± 13.1 vs. 47.0 ± 14.9), a larger proportion of females (62.4% vs. 37.0%), more unilateral lesions (80.4% vs. 41.6%), a lower incidence of the need for revision surgery (3.6% vs. 6.0%, = 0.004), and a higher proportion of in the culture (14.3% vs. 4.6%, < 0.001).

CONCLUSIONS

This large-scale study showed that are more commonly found in patients with fungal rhinosinusitis and in patients who needed revision surgery, suggesting that efforts aimed at eliminating are needed in order to improve the disease outcomes of patients with fungal rhinosinusitis.

摘要

背景

近年来真菌性鼻窦炎的发病率有所上升。我们通过对鼻窦手术获取的样本进行微生物培养，研究了真菌性鼻窦炎患者与非真菌性鼻窦炎患者微生物学检查结果的差异。

方法

利用长庚研究数据库，我们纳入了2001年至2019年期间所有接受过鼻窦手术且在手术期间进行了微生物培养的慢性鼻窦炎（CRS）患者。根据真菌培养和手术病理结果，将纳入的患者分为真菌组和非真菌组。

结果

共有898例患者被诊断为真菌性鼻窦炎，2884例为非真菌性鼻窦炎。真菌组患者年龄分布更高（56.9±13.1岁对47.0±14.9岁），女性比例更大（62.4%对37.0%），单侧病变更多（80.4%对41.6%），再次手术需求发生率更低（3.6%对6.0%，P=0.004），培养物中[此处原文缺失具体内容]比例更高（14.3%对4.6%，P<0.001）。