Department of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Department of Pathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Medicina (Kaunas). 2023 Sep 7;59(9):1616. doi: 10.3390/medicina59091616.
COVID-19-associated coinfections increase the patient's risk of developing a severe form of the disease and, consequently, the risk of death. The term "flurona" was proposed to describe the coinfection of the influenza virus and SARS-CoV-2. This report is about a case of a 7-month-old female infant who died due to flurona coinfection. A histopathological exam showed activation of microglia (becoming CD45 positive), bronchial inflammation, diffuse alveolar damage in proliferative phase with vasculitis, a peribronchial infiltrate that was predominantly CD20-positive, and a vascular wall infiltrate that was predominantly CD3-positive. The aggressiveness of the two respiratory viruses added up and they caused extensive lung inflammation, which led to respiratory failure, multiple organ failure, and death. Tissues injuries caused by both the influenza virus and SARS-CoV-2 could be observed, without the ability to certify the dominance of the aggression of one of the two viruses.
COVID-19 相关合并感染会增加患者发展为严重疾病的风险，进而增加死亡风险。“flurona”一词被用来描述流感病毒和 SARS-CoV-2 的合并感染。本报告介绍了一例因 flurona 合并感染而死亡的 7 个月大女婴病例。组织病理学检查显示小胶质细胞激活（CD45 阳性）、支气管炎症、弥漫性肺泡损伤伴增生期血管炎、以 CD20 阳性为主的支气管周围浸润和以 CD3 阳性为主的血管壁浸润。两种呼吸道病毒的侵袭性相加，导致广泛的肺部炎症，进而导致呼吸衰竭、多器官衰竭和死亡。可以观察到流感病毒和 SARS-CoV-2 引起的组织损伤，而无法确定两种病毒中哪一种的侵袭性占主导地位。
