Department of Dermatology, 4th Medical Centre, PLA General Hospital, Beijing, China.
Research Centre for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, Beijing, China.
Front Immunol. 2023 Feb 20;14:1092668. doi: 10.3389/fimmu.2023.1092668. eCollection 2023.
Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have been considered uncontrolled inflammatory responses, which have usually troubled patients around the world. Moreover, the recent method to treat AD and psoriasis has been based on the inhibition, not regulation, of the abnormal inflammatory response, which can induce a number of side effects and drug resistance in long-term treatment. Mesenchymal stem/stromal cells (MSCs) and their derivatives have been widely used in immune diseases based on their regeneration, differentiation, and immunomodulation with few adverse effects, which makes MSCs a promising treatment for chronic skin inflammatory diseases. As a result, in this review, we aim to systematically discuss the therapeutic effects of various resources of MSCs, the application of preconditioning MSCs and engineering extracellular vesicles (EVs) in AD and psoriasis, and the clinical evaluation of the administration of MSCs and their derivatives, which can provide a comprehensive vision for the application of MSCs and their derivatives in future research and clinical treatment.
慢性皮肤炎症性疾病包括特应性皮炎（AD）和银屑病，被认为是不受控制的炎症反应，这些疾病通常困扰着世界各地的患者。此外，最近治疗 AD 和银屑病的方法是基于抑制而不是调节异常炎症反应，这在长期治疗中会引起许多副作用和耐药性。间充质干细胞（MSCs）及其衍生物由于具有再生、分化和免疫调节作用，且副作用少，已广泛应用于免疫性疾病，这使得 MSCs 成为治疗慢性皮肤炎症性疾病的一种有前途的方法。因此，在这篇综述中，我们旨在系统地讨论各种 MSC 资源的治疗效果，预处理 MSC 和工程细胞外囊泡（EVs）在 AD 和银屑病中的应用，以及 MSC 及其衍生物给药的临床评价，为 MSC 及其衍生物在未来的研究和临床治疗中的应用提供全面的视角。
