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生物膜结构与年龄依赖性多形性

: Biofilm Architecture and Age-Dependent Pleomorphy.

作者信息

Desjardins Aléhandra, Zerfas Patricia, Filion Dominic, Palmer Robert J, Falcone Emilia Liana

机构信息

Center for Immunity, Inflammation and Infectious Diseases, Montreal Clinical Research Institute (IRCM), Montreal, QC H2W 1R7, Canada.

Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montreal, QC H3T 1J4, Canada.

出版信息

Microorganisms. 2023 Aug 31;11(9):2200. doi: 10.3390/microorganisms11092200.

DOI:10.3390/microorganisms11092200
PMID:37764045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10535455/
Abstract

Round bodies in spirochete cultures have been a controversial subject since their description seven decades ago. We report the existence of round bodies (spherical cells) in cultures of , a spiral bacterium phylogenetically distant from spirochetes. Furthermore, when grown in biofilms, demonstrates a unique morphology known as cording, which has been previously described only in mycobacteria. Thus, has two distinct features, each previously thought to be unique to two different phylogenetically distant groups of bacteria.

摘要

自七十年前首次描述以来,螺旋体培养物中的圆形体一直是一个有争议的话题。我们报告了在一种与螺旋体在系统发育上距离较远的螺旋细菌的培养物中存在圆形体(球形细胞)。此外,当在生物膜中生长时,该细菌表现出一种称为索状化的独特形态,这种形态以前仅在分枝杆菌中被描述过。因此,该细菌具有两个不同的特征,而每个特征以前都被认为是两个在系统发育上距离较远的不同细菌群体所特有的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/96eb41e99653/microorganisms-11-02200-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/e30056187a08/microorganisms-11-02200-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/ee5425eeed31/microorganisms-11-02200-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/de2f026d130b/microorganisms-11-02200-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/15b5991522cf/microorganisms-11-02200-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/96eb41e99653/microorganisms-11-02200-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/e30056187a08/microorganisms-11-02200-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/ee5425eeed31/microorganisms-11-02200-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/de2f026d130b/microorganisms-11-02200-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/15b5991522cf/microorganisms-11-02200-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b4d/10535455/96eb41e99653/microorganisms-11-02200-g005.jpg

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本文引用的文献

1
Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence.海分枝杆菌的表面刮削蛋白质组学鉴定出影响毒力、耐受性和持续性的生物膜亚型特异性变化。
mSystems. 2021 Jun 29;6(3):e0050021. doi: 10.1128/mSystems.00500-21. Epub 2021 Jun 22.
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The human symbiont Mucispirillum schaedleri: causality in health and disease.人类共生菌 Mucispirillum schaedleri:健康与疾病中的因果关系。
Med Microbiol Immunol. 2021 Aug;210(4):173-179. doi: 10.1007/s00430-021-00702-9. Epub 2021 May 22.
3
Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance.
牛型分枝杆菌三维低切变培养诱导生物膜形成和抗微生物药物耐受。
NPJ Biofilms Microbiomes. 2021 Feb 1;7(1):12. doi: 10.1038/s41522-021-00186-8.
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Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity.分枝杆菌在淋巴管内皮细胞内形成索状结构以逃避宿主免疫。
JCI Insight. 2020 May 21;5(10):136937. doi: 10.1172/jci.insight.136937.
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Lyme Disease Frontiers: Reconciling Biology and Clinical Conundrums.莱姆病前沿:协调生物学与临床难题
Pathogens. 2019 Dec 16;8(4):299. doi: 10.3390/pathogens8040299.
6
Intestinal Epithelial Cells Respond to Chronic Inflammation and Dysbiosis by Synthesizing HO.肠上皮细胞通过合成HO对慢性炎症和生态失调作出反应。
Front Physiol. 2019 Dec 12;10:1484. doi: 10.3389/fphys.2019.01484. eCollection 2019.
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Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson's disease.帕金森病患者的肠道微生物群改变和炎症细胞因子反应。
J Neuroinflammation. 2019 Jun 27;16(1):129. doi: 10.1186/s12974-019-1528-y.
8
Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis.沙氏穆菌拮抗沙门氏菌毒力以保护小鼠免受结肠炎。
Cell Host Microbe. 2019 May 8;25(5):681-694.e8. doi: 10.1016/j.chom.2019.03.004. Epub 2019 Apr 18.
9
The Role of Nitric Oxide in Regulating Intestinal Redox Status and Intestinal Epithelial Cell Functionality.一氧化氮在调节肠道氧化还原状态和肠上皮细胞功能中的作用。
Int J Mol Sci. 2019 Apr 9;20(7):1755. doi: 10.3390/ijms20071755.
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Helicobacter pylori Biofilm Involves a Multigene Stress-Biased Response, Including a Structural Role for Flagella.幽门螺杆菌生物膜涉及多基因应激反应,包括鞭毛的结构作用。
mBio. 2018 Oct 30;9(5):e01973-18. doi: 10.1128/mBio.01973-18.