Yang Yichi, Mori Mone, Wai Kyi Mar, Jiang Tao, Sugimura Yoshikuni, Munakata Wataru, Mikami Tatsuya, Murashita Koichi, Nakaji Shigeyuki, Ihara Kazushige
Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Microorganisms. 2023 Sep 11;11(9):2286. doi: 10.3390/microorganisms11092286.
Depression is a leading cause of disease worldwide. The association between gut microbiota and depression has barely been investigated in the Japanese population. We analyzed Iwaki health check-up data collected from 2017 to 2019 and constructed generalized linear mixed models. The independent variable was the relative abundance of each of the 37 gut microbiota genera that were reported to be associated with depression. The dependent variable was the presence of depression assessed by the Center for Epidemiologic Studies Depression Scale. Potential confounders, including grip strength, gender, height, weight, smoking, and drinking habits, were adjusted in the regression models. Nine genera's regression coefficients (, , , , , , , , and ) showed statistical significance after multiple comparisons adjustment. Among these nine gut bacteria genera, , , , , , and were reported to be associated with butyrate production in the intestine. Our results indicate that gut microbiotas may influence the depression condition of the host via the butyrate-producing process.
抑郁症是全球主要的致病原因。在日本人群中，肠道微生物群与抑郁症之间的关联几乎未得到研究。我们分析了2017年至2019年收集的磐城健康检查数据，并构建了广义线性混合模型。自变量是据报道与抑郁症相关的37种肠道微生物属中每种的相对丰度。因变量是通过流行病学研究中心抑郁量表评估的抑郁症的存在情况。在回归模型中对包括握力、性别、身高、体重、吸烟和饮酒习惯在内的潜在混杂因素进行了调整。经过多重比较调整后，9个属的回归系数（， ， ， ， ， ， ， ， ）显示出统计学意义。在这9种肠道细菌属中， ， ， ， ， ， 据报道与肠道中丁酸盐的产生有关。我们的结果表明，肠道微生物群可能通过丁酸盐产生过程影响宿主的抑郁状况。
