Shimm D S, Ropar M
Acta Obstet Gynecol Scand. 1986;65(5):449-52. doi: 10.3109/00016348609157382.
Twenty-two patients with invasive primary carcinoma of the vagina were treated with radiation therapy for cure between 1970 and 1980 at Massachusetts General Hospital. Eighteen demonstrated squamous cell carcinoma and six demonstrated adenocarcinoma. The 5-year actuarial survival was 0.38; no difference was noted between the different histologies. For stages I, II, III and IV disease, 5-year actuarial survivals were 0.71, 0.29, 0.48, and 0.52. A dose-response relationship could be demonstrated for both survival and local control. No serious complications were observed. On the basis of these results, increased reliance on implant techniques to increase the radiation dose to subvaginal tissues, is advocated in stage II disease.
1970年至1980年间，22例阴道浸润性原发性癌患者在马萨诸塞州总医院接受了旨在治愈的放射治疗。其中18例为鳞状细胞癌，6例为腺癌。5年精算生存率为0.38；不同组织学类型之间未发现差异。对于I期、II期、III期和IV期疾病，5年精算生存率分别为0.71、0.29、0.48和0.52。生存和局部控制均可显示出剂量反应关系。未观察到严重并发症。基于这些结果，对于II期疾病，主张更多地依赖植入技术来增加阴道下组织的放射剂量。
