Li Ninghua, Li Jing, Wang Hui, Qiao Yijuan, Li Weiqin, Gao Ming, Liu Enqing, Yu Zhijie, Hu Gang, Fang Zhongze, Leng Junhong, Yang Xilin
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China.
Nutrients. 2023 Sep 21;15(18):4089. doi: 10.3390/nu15184089.
To estimate associations of sulfur-containing amino acids (SAAs) in the early trimester of pregnancy and gestational diabetes mellitus (GDM) and estimate associations of maternal SAAs with adverse growth patterns in offspring.
We established a 1:1 matched case-control study (n = 486) from our cohort of pregnant women, and 401 children were followed up at ages 1 to 8 years. We conducted binary conditional logistic regression to estimate the risk associations of serum SAAs with GDM. Multinomial logistic regression was implemented to explore associations of maternal SAAs with adverse growth patterns in the offspring.
High serum methionine and cystine were independently associated with increased GDM risk (OR: 1.92, 95%CI: 1.18-3.13 and 2.69, 1.59-4.53). Conversely, a low level of serum taurine was independently associated with increased GDM risk (2.61, 1.64-4.16). Maternal high cystine and low taurine were also associated with an increased risk of persistent obesity growth pattern (POGP) in offspring (OR: 2.79, 95%CI: 1.09-7.17 and 3.92, 1.11-13.89) and the effect was largely independent of GDM.
High serum methionine, cystine and low serum taurine in the early trimester of pregnancy were associated with a greatly increased risk of GDM. Maternal high cystine and low taurine were associated with elevated risk of offspring POGP, largely independent of GDM.
评估妊娠早期含硫氨基酸（SAA）与妊娠期糖尿病（GDM）之间的关联，并评估母体SAA与子代不良生长模式之间的关联。
我们从孕妇队列中建立了一项1:1匹配的病例对照研究（n = 486），并对401名儿童进行了1至8岁的随访。我们进行二元条件逻辑回归以评估血清SAA与GDM的风险关联。实施多项逻辑回归以探索母体SAA与子代不良生长模式之间的关联。
高血清蛋氨酸和胱氨酸与GDM风险增加独立相关（比值比：1.92，95%置信区间：1.18 - 3.13和2.69，1.59 - 4.53）。相反，低水平的血清牛磺酸与GDM风险增加独立相关（2.61，1.64 - 4.16）。母体高胱氨酸和低牛磺酸也与子代持续性肥胖生长模式（POGP）风险增加相关（比值比：2.79，95%置信区间：1.09 - 7.17和3.92，1.11 - 13.89），且该效应在很大程度上独立于GDM。
妊娠早期高血清蛋氨酸、胱氨酸和低血清牛磺酸与GDM风险大幅增加相关。母体高胱氨酸和低牛磺酸与子代POGP风险升高相关，在很大程度上独立于GDM。
