Inoue W, Tomino Y, Miura M, Yagame M, Nomoto Y, Sakai H
Acta Pathol Jpn. 1986 Aug;36(8):1181-9. doi: 10.1111/j.1440-1827.1986.tb02838.x.
Deposition of immunoglobulins or acute phase reactant (APR) proteins in the dermal and glomerular capillary walls from patients with diabetes mellitus was examined to determine whether development of microangiopathy in such patients was related to exudation and/or entrapment of these proteins. Skin and renal biopsy specimens were obtained from patients with diabetic nephropathy and diabetes mellitus without nephropathy. These biopsy samples were stained with FITC-labeled anti-human IgG, IgA, IgM, C3, APR proteins, and beta-lipoprotein antisera. Linear depositions of IgA, IgG, and/or APR proteins were observed in the dermal and/or glomerular capillary walls from some patients with diabetic nephropathy or diabetes mellitus without nephropathy. It is indicated that deposition of such immunoglobulins in the dermal and glomerular capillary walls might be due to exudation and/or entrapment of these substances in patients with diabetes mellitus.
对糖尿病患者真皮和肾小球毛细血管壁中免疫球蛋白或急性期反应物（APR）蛋白的沉积情况进行了检查，以确定此类患者微血管病变的发展是否与这些蛋白的渗出和/或截留有关。从糖尿病肾病患者和无肾病的糖尿病患者身上获取皮肤和肾活检标本。这些活检样本用异硫氰酸荧光素（FITC）标记的抗人IgG、IgA、IgM、C3、APR蛋白和β-脂蛋白抗血清进行染色。在一些糖尿病肾病患者或无肾病的糖尿病患者的真皮和/或肾小球毛细血管壁中观察到IgA、IgG和/或APR蛋白的线性沉积。这表明，在糖尿病患者中，此类免疫球蛋白在真皮和肾小球毛细血管壁中的沉积可能是由于这些物质的渗出和/或截留所致。
