Pawłowska Agata Maria, Żurek Natalia, Kapusta Ireneusz, De Leo Marinella, Braca Alessandra
Department of Food Technology and Human Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza St., 35-601 Rzeszow, Poland.
Department of Pharmacy, University of Pisa, Via Bonanno Pisano 33, 56126 Pisa, Italy.
Plants (Basel). 2023 Sep 10;12(18):3221. doi: 10.3390/plants12183221.
Increasing interest in new sources of secondary metabolites as biologically active substances has resulted in an advanced study of many plant species. Loquat ( (Thunb.) Lindl. = (Lour.) Galasso & Banfi, Rosaceae family), an evergreen, subtropical fruit tree, native to China and Japan, but cultivated in southern countries of Europe, is a species commonly used in folk medicine and may be an excellent source of bioactive compounds. Therefore, the aim of the present study was to evaluate the profile of the phenolic constituents of fruits and leaves originating from Tuscany (Italy), as well as their in vitro antioxidant and chemopreventive activities on human cancer cell lines breast adenocarcinoma (MCF-7), colon adenocarcinoma (Caco-2 and HT-29), and glioblastoma (U87MG). Results revealed that the extract of leaves displayed higher antioxidant and anticancer potential than the fruit extract and contained 25 individual phenolic compounds that have been characterized and quantified by the UPLC-PDA-MS method. The antiproliferative activity was correlated with the content of polyphenolic compounds indicating that both fruits and leaves are a good source of antioxidants and may be exploited as nutraceuticals enriching food or as components for the cosmetic/pharmaceutical industry.
对作为生物活性物质的次生代谢产物新来源的兴趣日益增加，促使人们对许多植物物种进行了深入研究。枇杷（Eriobotrya japonica (Thunb.) Lindl. = Eriobotrya serrata (Lour.) Galasso & Banfi，蔷薇科）是一种常绿亚热带果树，原产于中国和日本，但在欧洲南部国家有种植，是一种常用于民间医学的植物，可能是生物活性化合物的优质来源。因此，本研究的目的是评估源自意大利托斯卡纳的枇杷果实和叶片中酚类成分的概况，以及它们对人癌细胞系乳腺癌（MCF-7）、结肠腺癌（Caco-2和HT-29）和胶质母细胞瘤（U87MG）的体外抗氧化和化学预防活性。结果表明，叶片提取物比果实提取物显示出更高的抗氧化和抗癌潜力，并且含有25种通过超高效液相色谱-光电二极管阵列-质谱法（UPLC-PDA-MS）进行了表征和定量的酚类化合物。抗增殖活性与多酚类化合物的含量相关，表明果实和叶片都是抗氧化剂的良好来源，可作为营养保健品用于丰富食品，或作为化妆品/制药行业的成分加以利用。
