镉对断奶大鼠脑组织脂质成分的影响。

Effect of cadmium on lipid composition of the weanling rat brain.

作者信息

Gulati S, Gill K D, Nath R

出版信息

Acta Pharmacol Toxicol (Copenh). 1986 Aug;59(2):89-93. doi: 10.1111/j.1600-0773.1986.tb00139.x.

DOI:10.1111/j.1600-0773.1986.tb00139.x

Abstract

The effect of early postnatal cadmium exposure (cadmium injected at dose levels of 1 and 2 mg cadmium/kg body weight on 3rd, 10th and 17th day after birth) on various lipid fractions of the weanling rat brain was studied. The results suggest that cadmium treatment (a dose of only 2 mg Cd/kg) results in an appreciable decrease in myelin-specific lipids like nonesterified cholesterol, ethanolamine-containing lipids, cerebrosides and sulfatides leading to hypomyelination. The lower dose of cadmium (1 mg Cd/kg) did not have any significant effect.

摘要

研究了出生后早期镉暴露（在出生后第3、10和17天以1和2毫克镉/千克体重的剂量注射镉）对断奶大鼠脑各种脂质组分的影响。结果表明，镉处理（仅2毫克镉/千克的剂量）导致髓鞘特异性脂质如非酯化胆固醇、含乙醇胺脂质、脑苷脂和硫脂明显减少，从而导致髓鞘形成不全。较低剂量的镉（1毫克镉/千克）没有任何显著影响。